October 2025 in “Dermatologic Surgery” This study found that hair follicles with twisted bulbs demonstrated similar survival rates to intact follicles after transplantation into nude mice, suggesting they may be viable for use in FUE surgery.
April 2026 in “Laboratory Animal Research” This study developed a novel Hairless Rag2/Jak3 KO mouse model, which provides superior optical properties and thinner skin compared to existing models, enhancing its utility for noninvasive tumor monitoring and evaluation of anticancer therapies.
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November 2015 in “Plastic and reconstructive surgery/PSEF CD journals” This study found that human skin grafted onto certain immunodeficient mice resulted in proliferative scars with characteristics similar to human hypertrophic scars, suggesting these models may better represent the condition's natural history.
January 2017 in “Journal of clinical & experimental dermatology research” This study found that human embryonic and induced pluripotent stem cells differentiated into specific bulge stem cells and successfully formed new hair follicles when transplanted with mouse dermal cells in immunodeficient mice.
This article reviews the history and characteristics of the rare nude phenotype SCID, primarily distinguished by severe T cell immunodeficiency and notable skin and hair abnormalities, but reports no new clinical findings.