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Dimethyl Fumarate Ameliorates Delayed Wound Healing Due to IL-36Ra Deficiency Through Inhibition of NET Formation and Oxidative Stress

research 1495 Dimethyl fumarate ameliorates delayed wound healing due to IL-36Ra deficiency through inhibition of NET formation and oxidative stress

April 2023 in “Journal of Investigative Dermatology”

This study found that dimethyl fumarate improved delayed wound healing in Il36rn-/- mice by reducing neutrophil extracellular trap formation and oxidative stress.

research IL-36α Promoted Wound Induced Hair Follicle Neogenesis via Hair Follicle Stem/Progenitor Cell Proliferation

7 citations , September 2020 in “Frontiers in Cell and Developmental Biology”

This study found that recombinant murine IL-36α increased the number of regenerated hair follicles and accelerated wound healing in a mouse model of wound-induced hair follicle neogenesis.

research The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier

23 citations , December 2021 in “Frontiers in Immunology”

This review discusses the significance of IL-1 family cytokines in skin inflammation and pathology, emphasizing their interactions with microbes and potential therapeutic applications, but reports no new clinical results.

research IL-36γ drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes

32 citations , December 2019 in “The Journal of clinical investigation/The journal of clinical investigation”

This study found that EGFR and MEK inhibitors may induce acneiform skin toxicities by interacting with the skin bacterium Cutibacterium acnes to increase IL-36γ and IL-8 production in keratinocytes.

research Alarmin Cytokines as Central Regulators of Cutaneous Immunity

51 citations , March 2022 in “Frontiers in Immunology”

This review discusses the regulatory roles of type 2 alarmin cytokines in skin immunity, focusing on their implications in host defense, chronic inflammation, and cancer, but reports no new clinical results.

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community Il PP405 è molto promettente ma non è l'unico in grado di liberarci dalla iattura

3 upvotes 1 year ago

PP405 shows promise in hair loss treatment, but stem cell therapy using adipose-derived stem cells and ATP also successfully reversed androgenetic alopecia in mice. Stem cell therapy is costly, and some doubt the effectiveness of PP405 based on press releases.

community Today I received my first Batch Follicopeptide

in Treatment 139 upvotes 7 months ago

A user purchased an expensive hair loss treatment called Follicopeptide, which many others in the conversation believe to be a scam, suggesting instead the use of proven treatments like minoxidil and finasteride. Some users report positive effects from Follicopeptide, but skepticism remains high due to lack of transparency about its ingredients and the company's credibility.

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