research 006 Exogenous IL-27 promotes immunosuppressive T cells and prevents the development of alopecia areata in C3H/HeJ mice
IL-27 may help prevent hair loss in alopecia areata by promoting immunosuppressive T cells.
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5 / 1000+ resultsresearch 0036 IL-27 generates immunosuppressive CD4 T cells and and prevents the development of alopecia areata
IL-27 may help prevent hair loss by creating immune-suppressing cells.
research Exogenous IL-27 prevents the development of alopecia areata
In a mouse model of alopecia areata, this study found that IL-27 overexpression using an adeno-associated virus protected against disease development, potentially by promoting immunosuppressive T cells and reducing CD8 T cell infiltration into hair follicles.
research CD4+ Treg expansion arrests disease progression in a pre-clinical model of alopecia areata
In this study, treatment with IL-2C to expand Tregs effectively halted hair loss progression in a murine model of alopecia areata.
research 035 Expansion of bacterial phosphatidylglycerol reactive CD4+ T cells in atopic dermatitis
This study found that CD1a-restricted CD4+ T cells responsive to lysyl-phosphatidylglycerol were more frequent in the blood of atopic dermatitis patients, suggesting a potential role in the disease's Th2-mediated pathology.
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