Search

for
Search:

Research

5 / 1000+ results

research Use of oral Janus kinase inhibitors for the treatment of severe alopecia areata: narrative review and real-world experience

March 2026 in “Immunological Medicine”

This review discusses the use of Janus kinase inhibitors for severe alopecia areata in Japan, noting their effectiveness in some patients but highlighting the need for new therapies due to non-responsiveness and relapse in others; it reports no new clinical results.

research Inflammatory loops in the epithelial–immune microenvironment of the skin and skin appendages in chronic inflammatory diseases

3 citations , September 2023 in “Frontiers in immunology”

This study discusses the epithelial-immune microenvironment in chronic skin diseases, such as psoriasis and atopic dermatitis, and highlights current and future treatment strategies targeting inflammatory loops within these diseases.

research Pathophysiology of Alopecia Areata in the Pediatric Patient

5 citations , March 2025 in “Pediatric Dermatology”

This study found that alopecia areata is linked to genetic factors, specifically HLA haplotypes on chromosome 6, and involves immune privilege collapse at hair follicles which is mediated by the JAK-STAT pathway and pro-inflammatory cytokines like IFN-γ.

research An overview of JAK/STAT pathways and JAK inhibition in alopecia areata

40 citations , August 2022 in “Frontiers in immunology”

This review discusses the potential of JAK inhibitors as a promising treatment strategy for alopecia areata, highlighting their mechanism and recent FDA approval based on clinical trial efficacy.