research Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male
This article reviews the coordination of the hypothalamic-pituitary-gonadal axis, male fertility, and therapies for hypogonadism, but reports no new clinical findings.
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research Sex differences in the hypothalamic–pituitary–adrenal axis’ response to stress: an important role for gonadal hormones
This review discusses sex differences in the neuroendocrine response to stress, focusing primarily on rodent studies, and highlights open questions about the roles of gonadal hormones and sex chromosomes.
research Alopecia areata – hyperactivity of the hypothalamic–pituitary–adrenal axis is a myth?
In this study, plasma levels of MSH and cortisol in patients with alopecia areata did not show significant changes compared to healthy controls.
research Hypothalamic-pituitary-adrenal axis, hair, and sebum: Stress-mediated dermatologic disasters of the pandemic era
This study highlights how the COVID-19 pandemic has exacerbated stress-related dermatological issues like acne and hair loss by affecting skin and hair cycles through stress hormones, emphasizing the need for comprehensive psychoneuroendocrine-informed approaches to diagnosis and treatment.
research Human Hair Follicles Operate a Functional Peripheral Equivalent of the Hypothalamic-Pituitary-Somatotropic Axis Ex Vivo
This article discusses the role of human scalp hair follicles in neurohormone production and their model potential for studying neuroendocrine signaling, reporting no experimental results.
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5 / 21 resultscommunity EMA is re-examining Winlevi (clascoterone at lower concentration)
Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.
community CB-03-01 / Breezula Personal Results
The user shared their experience with CB-03-01 (Breezula/Clascoterone) for hair loss, noting reduced shedding and improved hair appearance but experiencing significant sleep disturbances and low energy due to HPA axis suppression. They decided to stop using it due to these side effects and are waiting for GT20029 as an alternative.
community There’s actually a quite good chance that next year, we might see a new treatment get FDA approval for the first time in nearly three decades.
Breezula, a potential new hair loss treatment, may receive FDA approval soon, but it is expected to be a weaker alternative to finasteride and minoxidil. Concerns include its twice-daily application and possible side effects like HPA axis suppression.
community Mechanism of action of alfatradiol (17 alpha estradiol)
The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.
community Methods Of Staying Safe On Ru58841 - My 2 Cents
RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.
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