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GlossaryPigmentation Disorders

conditions affecting skin, hair, or eye color due to melanin abnormalities

Pigmentation disorders are conditions that affect the color of your skin, hair, or eyes due to abnormal melanin production. These disorders can result in patches of skin that are lighter (hypopigmentation) or darker (hyperpigmentation) than the surrounding areas, and can be caused by genetic factors, sun exposure, or underlying health issues.

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research Regulation of Melanocyte Stem Cell Behavior by the Niche Microenvironment

24 citations, March 2018 in “Pigment Cell & Melanoma Research”

The environment around melanocyte stem cells is key for hair regeneration and color, with certain injuries affecting hair color and potential treatments for pigmentation disorders.

research Epimedium Brevicornum Maxim Extract Enhances Melanin Biosynthesis and Melanosome Biogenesis/Transfer

6 citations, September 2022 in “Frontiers in pharmacology”

Epimedium extract helps increase skin pigmentation and could be a new treatment for conditions with reduced pigmentation.

research Transgenic Endothelin 3 Regulates Murine Pigment Production and Coat Color

October 2017

The gene Endothelin 3 makes mice's fur darker by increasing pigment cells and pigment levels.

research A Rational Approach to the Treatment of Vitiligo and Other Hypomelanoses

19 citations, July 2007 in “Dermatologic clinics”

Tailor treatments for vitiligo to patient needs for best results.

research Managing the Hair and Skin of African American Pediatric Patients

6 citations, March 1999 in “Journal of pediatric health care”

The document emphasizes the need for primary care providers to understand and care for African American children's hair and skin to boost their self-esteem.

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community Can tretinoin cause problems or issues with min?

in Minoxidil 2 upvotes 3 days ago

The user is using a topical routine of finasteride and minoxidil, noticing increased hair growth, and is considering adding tretinoin for skin issues. Tretinoin may enhance minoxidil's effectiveness, but care should be taken to allow proper absorption to avoid unintended facial hair growth.

community Massive preliminary success with my thorough regime

in Update 4 upvotes 4 years ago

A 28-year-old male reported significant hair regrowth after 5 weeks using a regime including Minoxidil, Ketozolin shampoo, microneedling, hyaluronic acid, saw palmetto, pumpkin seed, MSM, frankincense, zinc, multivitamins, and vitamin D. He also noted improvements in digestion, dry eyes, and skin health, and observed beard growth from microneedling.

community Does finasteride/dutasteride reverse aging?

in Chat 45 upvotes 5 months ago

Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

community Started Finasteride almost three months ago and I'm upset

in Update 153 upvotes 1 year ago

A user started taking finasteride three months ago to treat hair loss and unexpectedly cleared their acne, which they had been struggling with since age 12. The conversation includes others sharing their experiences with finasteride, its effects on acne and hair loss, and mentions a related treatment, clascoterone, for acne and hair loss.

community Microneedling makes a difference. Non responders, please read

in Microneedling 66 upvotes 1 year ago

A 48-year-old who had been thinning since 25 and reached NW4-5 baldness saw no improvement with 1mg/day finasteride and 5% minoxidil twice a day after 8 months. After copying another person's routine, they now use 0.5mg finasteride, ketoconazole shampoo weekly, daily microneedling with 0.5mm and 1mm once a week, and apply minoxidil twice daily, resulting in baby hairs on their bald spot and temples after three months.

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