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This narrative review concluded that facial aging involves complex anatomical changes that require multimodal rejuvenation approaches, integrating fillers, collagen stimulators, botulinum toxin, and energy-based devices for effective results, while emphasizing the need for scientific evidence and patient safety in aesthetic treatments.

This study found that while hyaluronic acid fillers can enhance facial balance and aesthetics, particularly in the temple area, they carry significant risks like vascular occlusion and blindness, highlighting the need for careful technique and product selection to ensure safety.

In this study, hyaluronic acid filler injections in albino rats increased subcutaneous tissue thickness, collagen and elastic fibers, and vascularization, suggesting potential benefits for combating skin aging and defects.

This study examined a case of vascular complication following the use of hyaluronic acid-based fillers in lateral temporal lifting, resulting in livedo reticularis, alopecia, and painful injection area requiring three months of treatment.

This review suggests that dermatological cosmetic procedures can be safely performed on dark-complexioned skin with appropriate treatment adjustments, highlighting the need for careful consideration to prevent adverse effects.