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GlossaryHomeobox Genes

regulatory genes controlling body plan and organ development

Homeobox genes, often referred to as Hox genes, are a group of regulatory genes that play a crucial role in determining the body plan and the formation of tissues and organs during early embryonic development. They contain a specific DNA sequence called the homeobox, which encodes a protein domain (the homeodomain) that can bind to DNA and regulate the expression of other genes. This precise regulation ensures that body structures form in the correct locations.

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research Hox in the Niche Controls Hair Heterogeneity

4 citations, October 2018 in “Cell Stem Cell”

Hox genes control hair growth patterns in mammals by regulating stem cell activity in the skin.

research Hox Demarcates Regional Regeneration of Adult Hair Follicle Stem Cells

June 2017 in “Mechanisms of development”

Hox genes control hair follicle stem cell regeneration in different body regions.

Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation

research Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation

65 citations, July 2006 in “Journal of biological chemistry/The Journal of biological chemistry”

The gene Foxq1, controlled by Hoxc13, is crucial for hair follicle differentiation.

research Specific Ectodermal Enhancers Control the Expression of Hoxc Genes in Developing Mammalian Integuments

June 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The HoxC gene cluster and its enhancers are essential for developing hair and nails in mammals.

research Distinct Mechanisms Underlie Pattern Formation in the Skin and Skin Appendages

25 citations, September 2006 in “Birth Defects Research”

Different processes create patterns in skin and things like hair and feathers.

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community Is it possible for androgenic alopecia to begin at early adolescent years?

in Chat 70 upvotes 1 year ago

Hair loss can begin in early adolescence and cause mental anguish. Treatments mentioned include eating cruciferous vegetables, engaging in physical activity, and maintaining scalp hygiene.