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GlossaryHomeobox Genes

regulatory genes controlling body plan and organ development

Homeobox genes, often referred to as Hox genes, are a group of regulatory genes that play a crucial role in determining the body plan and the formation of tissues and organs during early embryonic development. They contain a specific DNA sequence called the homeobox, which encodes a protein domain (the homeodomain) that can bind to DNA and regulate the expression of other genes. This precise regulation ensures that body structures form in the correct locations.

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research A Multi-Scale Spatial Atlas of Human Skin Links Cancer Cell States to Site of Origin

April 2023 in “Journal of Investigative Dermatology”

The research shows that skin cancer likely originates from hair follicles and that certain cell populations expand to promote skin cancer growth.

research The Hairless Gene of the Mouse

4 citations , May 2006 in “médecine/sciences”

The hairless gene is crucial for hair health, and its mutations cause hair loss.

research Hox in the Niche Controls Hair Heterogeneity

4 citations , October 2018 in “Cell Stem Cell”

Hox genes control hair growth patterns in mammals by regulating stem cell activity in the skin.

research Hoxc13 And The Development Of Hair Follicle

10 citations , August 2010 in “Hereditas (Beijing)”

Hoxc13 is essential for hair growth and follicle development.

research Malignant Melanoma and Its Stromal Nonimmune Microecosystem

10 citations , January 2012 in “Journal of Oncology”

The surrounding tissue plays a crucial role in the growth and spread of skin cancer.

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community Is it possible for androgenic alopecia to begin at early adolescent years?

in Chat 70 upvotes 2 years ago

Hair loss can begin in early adolescence and cause mental anguish. Treatments mentioned include eating cruciferous vegetables, engaging in physical activity, and maintaining scalp hygiene.