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research Geographic Variation and Host Genetics Shape the Human Skin Microbiome

May 2025

In this research, geography was found to explain more variation in the human skin microbiome than skin type, while host genetics contributed unique microbial structures, highlighting their role in skin microbiome ecology through extensive genomic and metagenomic analyses in a diverse international cohort.

research Host Genetic Susceptibility and Impacts of Dietary Factors on Covid-19

February 2022 in “International journal of KIU”

This review discusses genetic susceptibility and dietary factors influencing COVID-19 severity and summarizes the genetic variants linked to infection outcomes, but it reports no new clinical results.

research TMPRSS2: A Key Host Factor in SARS-CoV-2 Infection and Potential Therapeutic Target

4 citations , June 2025 in “Medeniyet Medical Journal”

This review explores the role of the TMPRSS2 gene in facilitating SARS-CoV-2 infection and its potential as a therapeutic target in COVID-19 and other respiratory infections, highlighting challenges in developing selective inhibitors.

research Genetic Variants and Protective Immunity against SARS-CoV-2

5 citations , December 2022 in “Genes”

This review discusses the host genetic factors influencing COVID-19 susceptibility and pathogenesis, highlighting genetic variations that affect viral entry and immune responses, but reports no new experimental results.

research 308 Epidermal keratinocytes regulate bacterial immune responses and host defense through EGFR

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study using a genetic mouse model found that S. aureus-driven dysbiosis sustains inflammatory skin side effects from EGFR inhibitors, suggesting prophylactic antibiotic treatment may reduce rash severity without fixing barrier defects.

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community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community DHT Itch and Oily Scalp Explained (and how to fix it)

90 upvotes 3 months ago

Malassezia overgrowth can worsen oily scalp and inflammation, contributing to hair loss. Treatments include antifungal shampoos, C6/C8 MCT oil, low-dose isotretinoin, finasteride, and dutasteride.

community If minox causes facial wrinkles, then I should mix my Min/Fin for 1 dose daily, not 2?

4 upvotes 4 years ago

Minoxidil may cause facial aging, possibly due to alcohol and propylene glycol (PG) content. The user plans to reduce Minoxidil and Finasteride to one daily dose to minimize these effects.

community 18 months Dut - Shed after shed without any gains

in Update 115 upvotes 1 year ago

Dutasteride caused persistent hair shedding and no improvement for 18 months, leading to a switch back to finasteride. The user also uses oral minoxidil and plans to focus on better scalp health.

community [22m] Is it time for a transplant?

in Progress Pictures 56 upvotes 1 year ago

A 22-year-old is experiencing aggressive hair loss despite using minoxidil and finasteride and is considering a hair transplant but lacks funds. The discussion includes advice on treatments like dutasteride, microneedling, and lifestyle changes, with mixed opinions on the timing and effectiveness of a transplant at a young age.

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