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Patterns of Psychotropic Medication Prescribing and Potential Drug-Hormone Interactions Among Transgender and Gender-Diverse Adults Within 2 Years of Hormone Therapy

research Patterns of psychotropic medication prescribing and potential drug-hormone interactions among transgender and gender-diverse adults within 2 years of hormone therapy

1 citations , January 2024 in “Journal of the American Pharmacists Association”

In this study of transgender and gender-diverse adults, the researchers observed that one-third of those on psychotropic medications within two years of starting hormone therapy experienced psychotropic polypharmacy, with a significantly higher likelihood of potential drug-hormone interactions in this group.

Medications Affecting the Insulin-Like Growth Factor 1/Growth Hormone Axis, Including Teprotumumab, Somatostatin Analogs, and Anti-Calcitonin Gene-Related Peptide Monoclonal Antibodies, Are Associated With Elevated Reporting Odds of Alopecia in Women: A Pharmacovigilance Study

research Medications affecting the insulin-like growth factor 1/growth hormone axis, including teprotumumab, somatostatin analogs, and anti-calcitonin gene-related peptide monoclonal antibodies, are associated with elevated reporting odds of alopecia in women: A pharmacovigilance study

April 2023 in “Journal of The American Academy of Dermatology”

This study investigated the association between hair loss and medications affecting the GH/IGF-1 pathway, using the FDA Adverse Event Reporting System to analyze reporting odds ratios of alopecia.

research Medications Altering Sex Hormone Balance and Risk of Advanced Liver Disease in HCV-infected Males

October 2011 in “The American Journal of Gastroenterology”

This study found that methadone use in HCV-infected male veterans was associated with a significant increase in the risk of advanced liver fibrosis.

Sex Hormones And The Skin: Questionnaire For Practicing Veterinarians. Bibliographic Update And Synthesis

research Les hormones sexuelles et la peau : questionnaire à l'attention des vétérinaires praticiens. Mise à jour bibliographique et synthèse

January 2014 in “HAL (Le Centre pour la Communication Scientifique Directe)”

This review provides an update on sex hormone-associated dermatoses in dogs, detailing known conditions like feminization syndrome and exploring less understood issues such as alopecia X, without presenting new clinical findings.

research Testosterone: The Forgotten Female Hormone

2 citations , March 2025 in “Lynchburg Journal of Medical Science”

This literature review highlights varying recommendations for testosterone use in peri- and postmenopausal women, noting its accepted role in treating hypoactive sexual desire disorder but stressing controversy and lack of FDA-approved options for broader use.

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Community Join

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community Taking HRT medication not only cured my thinning hair, it gave me better hair than I ever had before

in Transgender 12 upvotes 9 months ago

Hormone replacement therapy with spironolactone and estradiol significantly improved hair thickness and growth, surpassing previous treatments like dutasteride, finasteride, and minoxidil. The user experienced regrowth in receded areas and a more youthful appearance.

community We are manipulating our hormones, surely it's prudent to track bloodwork ?

in Finasteride/Dutasteride 64 upvotes 2 years ago

The conversation discusses whether individuals using hair loss treatments like Dutasteride (Dut) or Finasteride (Fin) should regularly check their hormone levels through bloodwork. Some argue it's important to monitor the effects of these medications on hormone levels, while others believe it's unnecessary if there are no side effects, citing cost and practicality concerns.

community Any other non-responders to most medications?

6 upvotes 3 years ago

The user has not seen results from various hair loss treatments including finasteride, dutasteride, minoxidil, and others over several years and is considering adding RU58841 and starting hormone replacement therapy. They are also experiencing anxiety and contemplating moving to a more accepting environment for their nonbinary identity.

community Claim: Insulin resistance increases the enzyme that creates DHT and affects the liver's ability to control hormones

in Research/Science 4 upvotes 11 months ago

Insulin resistance may increase DHT production, contributing to hair loss, and addressing it through diet, nutrients, and natural DHT blockers like saw palmetto and pumpkin seed oil could help reverse hair loss. Some users prefer medications like finasteride for more effective results.

community literally dht beef bruhhsmhmmhh😡😡😡😡😡😤

in Finasteride/Dutasteride 128 upvotes 1 year ago

The conversation discusses using finasteride, dutasteride, RU58841, and testosterone to combat hair loss and block DHT, with some users expressing concerns about side effects and vegan options for medication. The discussion also touches on personal experiences with hormone treatments and the desire to maintain a youthful appearance.

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Learn

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learn Bicalutamide

a nonsteroidal anti-androgen, most commonly used orally for women

learn Hydrocortisone

a synthetic cortisol used for anti-inflammatory effects

learn Fluridil

a topical anti-androgen with less systemic involvement

learn Overview

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Centella

Sensitive to hormones? A centella scalp mask may help ease hidden inflamm Centella asiatica has anti-inflammatory and wound-healing effects in animal and cell studies, but no published research has tested a centella scalp mask on the human scalp, in hormonal contexts or otherwise, and no community reports were found of one being used this way.

learn Estradiol

Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol helps treat hair loss by balancing hormones and supporting hair follicle health.
Is applying Estradiol directly to the scalp effective for hormone-related hair thinning? Applying Estradiol directly to the scalp may help with hormone-related hair thinning.

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

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