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research A Retrospective Cohort Study of Transgender Adolescents' Gender-Affirming Hormone Discontinuation

8 citations , January 2025 in “Journal of Adolescent Health”

In this retrospective cohort study, researchers found that persistent discontinuation of gender-affirming hormones among transgender adolescents was rare, mainly due to achieving gender expression goals or access issues, with very few reidentifying with their birth-assigned sex.

Successful Discontinuation of Levothyroxine in a Known Case of Hypothyroidism Through Personalized Homeopathic Treatment: An Evidence-Based Case Report

research Successful discontinuation of levothyroxine in a known case of hypothyroidism through personalised homoeopathic treatment: An evidence-based case report

December 2025 in “Journal of Integrated Standardized Homoeopathy”

This case report describes the use of individualized homoeopathic treatment and dietary modifications to manage hypothyroidism in a 23-year-old woman, resulting in symptom improvement and normalized TSH levels after tapering off levothyroxine.

research Finasteride and male infertility: a case for prospective collaborative research databases?

1 citations , September 2013 in “Fertility and Sterility”

Finasteride discontinuation increases sperm count in men.

research Estrogen deprivation effects of endocrine therapy in breast cancer patients: Incidence, management and outcome

7 citations , September 2023 in “Cancer Treatment Reviews”

This review highlights the possible impact of side effects from endocrine therapy on quality of life, emphasizing that these can lead to poor adherence and early treatment discontinuation in patients with hormone receptor positive early breast cancer, potentially worsening survival outcomes.

research Association of Surgical Risk With Exogenous Hormone Use in Transgender Patients

57 citations , December 2018 in “JAMA Surgery”

This systematic review suggests that current evidence does not support routinely discontinuing gender-affirming hormone treatments before surgery, especially testosterone and spironolactone, due to limited data on related perioperative risks.

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community Could topical finasteride have doubled my estradiol?

in Finasteride/Dutasteride 2 upvotes 1 year ago

The user experienced high estradiol levels after using topical finasteride at 0.1 mg/day, which normalized after discontinuation. They are questioning if this low dosage could significantly impact hormone levels.

community Finasteride - impact on Neurosteroids, which yes, \are important and not a garbage hormone

in Research/Science 163 upvotes 1 year ago

Finasteride may affect neurosteroids, impacting mood and sexual function, with varied user experiences. Some report side effects like depression and sexual dysfunction, while others find it effective for hair retention or prefer alternatives like Dutasteride or topical treatments.

community How an SSRI seemed to help my hairloss

7 upvotes 3 years ago

An SSRI (paroxetine) reduced hair loss and itching for a user with male-pattern baldness, but liver issues forced discontinuation, leading to increased hair loss and anxiety. The user plans to try other anti-anxiety medications, noting stress and anxiety significantly impact hair loss.

community My Journey on Fin + Min (19M giving up)

18 upvotes 1 year ago

A 19-year-old tried oral minoxidil and finasteride for hair loss but experienced side effects like fatigue, dry eyes, and lack of motivation, leading to discontinuation. Suggestions included trying topical treatments, dutasteride, or accepting hair loss.

community Taking Charge of Your Hair: The "Big 3 Stack" Explained for 2023

129 upvotes 3 years ago

The "Big 3 Stack" for hair loss treatment, which includes Minoxidil for hair density improvement, Ketoconazole shampoo for enhancing hair volume and thickness, and Finasteride for blocking hair loss causing hormones. Microneedling can boost Minoxidil's effects.

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Learn

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learn Overview

learn Centella

Sensitive to hormones? A centella scalp mask may help ease hidden inflamm Centella asiatica has anti-inflammatory and wound-healing effects in animal and cell studies, but no published research has tested a centella scalp mask on the human scalp, in hormonal contexts or otherwise, and no community reports were found of one being used this way.

learn Estradiol

Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol helps treat hair loss by balancing hormones and supporting hair follicle health.
Is applying Estradiol directly to the scalp effective for hormone-related hair thinning? Applying Estradiol directly to the scalp may help with hormone-related hair thinning.

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

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