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      learn Follistatin

      glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

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      An essential vasodilator with some anti-androgenic effects, has excellent safety record

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      highly targeted anti-androgen that might have minimal systemic effects

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      a potent but unapproved and potentially problematic topical anti-androgen

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      a traditional, natural remedy touted for promoting scalp health and hair growth

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      community Hair loss - Blood work (High DHEAS)

      in Research/Science  7 upvotes 4 years ago
      A user has been taking finasteride for 5 months with no improvement in diffuse hair loss and suspects high levels of prolactin, cortisol, progesterone, and DHEAS, as well as iron, might be contributing to the issue. They are also taking vitamin D to address a deficiency.

      community 31M - major hair shedding after weight loss + stopping vitamins — help!

      in Minoxidil  4 upvotes 9 months ago
      A 31-year-old male experienced hair shedding after rapid weight loss and stopping vitamins, despite using minoxidil and other supplements. He is considering Saw Palmetto and Pumpkin Seed Oil instead of finasteride due to trying for kids, and is concerned about high ferritin and DHEAS levels.

      community DHEA, the culprit behind DUPA ? Read this!

      in Research/Science  19 upvotes 2 years ago
      High DHEA levels may contribute to hair loss by increasing DHT in hair follicles, potentially explaining why finasteride is ineffective for some. Treatments like high-dose dutasteride and RU58841 are suggested, but the underlying cause, such as adrenal issues, should be investigated.