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Did you mean Heme Oxygenase-1?

Glossary Heme Oxygenase-1

breaks down heme into biliverdin, iron, and carbon monoxide

Heme Oxygenase-1 (HO-1) is an enzyme that plays a crucial role in breaking down heme, a component of hemoglobin, into biliverdin, free iron, and carbon monoxide. This process not only helps in recycling iron but also has anti-inflammatory and antioxidant effects, which can protect cells from damage.

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Research

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research Heme Oxygenase and the Skin in Health and Disease

9 citations , July 2018 in “Current Pharmaceutical Design”

This review discusses the importance of heme oxygenase in skin physiology and disease, but it reports no new clinical results; the authors highlight its potential as a treatment target for conditions like atopic dermatitis and psoriasis.

Correlations Between Soluble Receptor for Advanced Glycation End Products and Heme Oxygenase-1 in Post-COVID-19 Patients With Telogen Effluvium

research Correlations between soluble receptor for advanced glycation end products and heme oxogenase-1 in post-COVID-19 patients with telogen effluvium

May 2026 in “Journal of the Egyptian Womenʼs Dermatologic Society”

This study found that post-COVID-19 telogen effluvium is strongly associated with elevated oxidative stress marker sRAGE and reduced antioxidant marker HO-1, suggesting potential biomarkers for early diagnosis and monitoring.

research PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from Eclipta prostrata L.

6 citations , December 2020 in “Biological & Pharmaceutical Bulletin”

This study found that certain fatty acids and triterpenoid-glycosides from Eclipta prostrata L. leaves exhibit potent inhibitory effects on the protein tyrosine phosphatase 1B enzyme, suggesting potential anti-diabetic and anti-obesity benefits.

research 4‐octyl itaconate alleviates cisplatin‐induced ferroptosis possibly via activating the NRF2/HO‐1 signalling pathway

1 citations , March 2024 in “Journal of Cellular and Molecular Medicine”

In this study, researchers found that 4-Octyl itaconate (4-OI) inhibited cisplatin-induced ferroptosis and protected auditory cells by activating the NRF2/HO-1 signaling pathway, suggesting a potential therapeutic approach for reducing hearing loss associated with cisplatin treatment.

Aqueous Extract of Mentha Suaveolens Induces Nrf-2 Activation and Expression of Antioxidant and Detoxifying Enzymes in Human Keratinocyte HaCaT

research 1316 Aqueous extract of Mentha suaveolens induces Nrf-2 activation and expression of antioxidant and detoxifying enzymes in human keratinocyte HaCaT

April 2018 in “Journal of Investigative Dermatology”

This study found that Mentha suaveolens aqueous extract activated Nrf-2 and increased detoxifying enzyme expression in keratinocytes, providing protection against oxidative stress without cytotoxicity.

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