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research Linc-PINT downregulation of TGF-β signaling pathway in heart arrhythmia: an in silico analysis

April 2025 in “Journal of Diabetes & Metabolic Disorders”

This study found that linc-PINT expression was significantly decreased in patients with atrial fibrillation compared to healthy controls, while several TGF-β signaling genes were increased, suggesting a potential role in heart arrhythmias' pathogenesis.

research CARDIOVASCULAR SAFETY OF LOW-DOSE ORAL MINOXIDIL FOR ANDROGENETIC ALOPECIA IN PATIENTS WITH HYPERTENSION OR ARRHYTHMIAS

August 2026 in “LUMEN ET VIRTUS”

In this study, low-dose oral minoxidil for androgenetic alopecia was generally safe, showing small average changes in blood pressure and heart rate with infrequent cardiovascular issues, though monitoring is essential, especially in patients with conditions like hypertension or arrhythmias.

research Forensic approach in cases of anabolic-androgenic steroid abuse and cardiovascular mortality: insights from autopsy, histopathology, immunohistochemistry and toxicology

1 citations , October 2025 in “Frontiers in Cardiovascular Medicine”

This review examines AAS-related deaths and finds that anabolic-androgenic steroid abuse may lead to severe cardiac abnormalities, contributing to fatal arrhythmias and sudden cardiac death in young athletes and bodybuilders.

research Cardiovascular risk in patients with selected cutaneous diseases

May 2022 in “Journal of Education, Health and Sport”

This review discusses the associations between dermatological disorders and increased cardiovascular risk, emphasizing that skin conditions with chronic inflammation may elevate the likelihood of cardiovascular diseases.

research Reporting on Adverse Clinical Events

November 2015 in “Clin-Alert”

Some medications and supplements can cause serious side effects, including hair loss, heart rhythm problems, liver injury, and other health issues.

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Community Join

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community Topical minoxidil + dermarolling gave me heart arrhythmia (PVCs) — sharing my experience, not trying to scare anyone

250 upvotes 1 week ago

Using topical minoxidil with dermarolling can lead to heart arrhythmia due to increased absorption. Users report cardiac side effects, suggesting caution when combining these treatments.

community The Biggest Concern That I Have For Oral Minoxidil: Cardiac Hypertrophy

26 upvotes 3 years ago

Oral minoxidil can cause serious heart issues like cardiac hypertrophy and arrhythmias, prompting some users to reduce dosage or switch to topical treatments. Despite significant hair regrowth, side effects such as shortness of breath and chest pains are common concerns.

community Serious Oral Minoxidil Side Effects

30 upvotes 5 years ago

A user experienced severe side effects, including heart-related symptoms, after increasing their oral minoxidil dosage to 5 mg, leading them to stop the medication and seek medical advice. Many users advised against high doses of oral minoxidil, suggesting anxiety as a possible cause, and recommended consulting a doctor or switching to topical treatments.

community Success with .5mg oral fin and 1.25 mg oral min

in Finasteride/Dutasteride 4 upvotes 4 months ago

Users discussed using lower doses of finasteride and minoxidil for hair loss. Some experienced side effects like arrhythmia, while others reported slowed hair thinning but not complete prevention.

community Is RU58841 making a comeback? Is it worth it?

5 upvotes 3 weeks ago

RU58841 is being reconsidered as a hair loss treatment, with some users reporting early positive signs, though concerns about potential heart issues exist. Alternatives like KX826 and traditional treatments like dutasteride and minoxidil are also discussed.

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Learn

2 / 9 results

learn capsicum

Can the heat from capsicum actually wake up dormant hair follicles? There is no good evidence that capsicum on the scalp wakes dormant follicles. The one positive human study gave capsaicin by mouth with soy isoflavone.

learn Minoxidil

What are the side effects of minoxidil, and can oral minoxidil affect your heart? Minoxidil tablets are a blood-pressure drug whose US label carries a boxed warning for fluid around the heart (pericardial effusion, sometimes tamponade) and worsening angina; use for hair loss is off-label, and studies of low doses describe mostly mild effects but rare serious heart events. Do not start or change minoxidil without a doctor, and if chest pain, a racing heartbeat, breathlessness, fainting, swelling or rapid weight gain develop, stop and seek medical care.

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