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Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

356 citations, December 1986 in “The journal of cell biology/The Journal of cell biology”

Hair and nail cells share similar proteins, indicating a common differentiation pathway.

research Convergent Evolution of Cysteine-Rich Keratins in Hard Skin Appendages of Terrestrial Vertebrates

36 citations, November 2019 in “Molecular biology and evolution”

Cysteine-rich keratins evolved independently in mammals, reptiles, and birds for hard skin structures like hair, claws, and feathers.

research Skin Appendage Proteins of Tetrapods: Building Blocks of Claws, Feathers, Hair, and Other Cornified Epithelial Structures

February 2025 in “Animals”

Understanding proteins in skin structures like claws and hair is crucial for future research.

research Alopecia Areata: Pathogenesis, Genetic Factors, and Treatments Using Mouse Models

24 citations, January 2008 in “KARGER eBooks”

The document concludes that ongoing research using animal models is crucial for better understanding and treating Alopecia Areata.

research The RAIG Family Member, GPRC5D, Is Associated With Hard-Keratinized Structures

64 citations, March 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

GPRC5D is linked to the formation of hair, nails, and certain tongue areas.

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community DIY treatment... Shedding completely stopped after 1.5 yrs

in Treatment 249 upvotes 3 years ago

Vitamin C mixed with shampoo stopped shedding and promoted hair regrowth after 1.5 years. Both the person and their wife experienced significant hair loss reduction with this method.

community Topical minoxidil brand (and form of application) matters. You can be a hyper-responder to one product and a non-responder to another.

in Minoxidil 15 upvotes 1 month ago

Different minoxidil formulations affect hair growth and side effects. Higher propylene glycol and pH levels improve effectiveness but can cause scalp irritation.

community Should I apply my grapefruit topically instead of injecting it into my bloodstream?

in Satire 74 upvotes 1 year ago

The conversation is a satirical discussion about using grapefruit for hair regrowth, with suggestions ranging from injecting it to applying it topically or anally. Some users claim unusual benefits like emitting a green aura or jumping high.

community Got a microscope camera. Here’s the difference between healthy and miniaturized hair

in Progress Pictures 492 upvotes 2 years ago

A user who shared progress pictures of their scalp using a microscope camera, demonstrating the difference between healthy and miniaturized hair. Various explanations for the cause of this were discussed, such as DHT build-up in scalp sebum causing an autoimmune response leading to inflammation and eventual hair loss, with some suggesting a do-it-yourself treatment involving adding ascorbic acid powder to shampoo.

community No gains after 4 years of min and fin

in Progress Pictures 92 upvotes 8 months ago

User has seen no improvement after 4 years of using minoxidil and finasteride, and recently started dutasteride. Suggestions include adding oral minoxidil, microneedling, and considering a hair transplant.

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