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    Did you mean Hand-Foot Syndrome?
    Glossary Hand-Foot Syndrome

    causes redness, swelling, and pain on palms and soles

    Hand-Foot Syndrome, also known as Palmar-Plantar Erythrodysesthesia (PPE), is a side effect of certain chemotherapy drugs. It causes redness, swelling, and pain on the palms of the hands and the soles of the feet, and in severe cases, can lead to blistering and peeling of the skin. This condition occurs because the chemotherapy drugs leak out of the capillaries in these areas, leading to inflammation and damage.

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    1. Pathogenesis of Hand-Foot Syndrome induced by PEG-modified liposomal Doxorubicin Human cell · 2013 · 63 citations
    2. Prophylaxis and Management of Skin Toxicities Breast care · 2019 · 15 citations
    3. Skin toxicity induced by chemotherapy or molecular targeted therapy combined with immune checkpoint inhibitors in Asian patients: A literature review by the Japanese Pharmacist-led Oncodermatology Study Team International Journal of Clinical Oncology · 2026
    4. Chemotherapy and the Skin: Understanding Dermatologic Side Effects Cureus · 2026
    5. Skin toxicity of anti‐cancer therapy Journal der Deutschen Dermatologischen Gesellschaft · 2008 · 19 citations
    6. Targeted Therapy– and Chemotherapy-Associated Skin Toxicities: Systematic Review and Meta-Analysis Oncology nursing forum · 2020 · 6 citations
    7. Deferasirox, an oral iron chelator, prevents hepatocarcinogenesis and adverse effects of sorafenib Journal of clinical biochemistry and nutrition · 2016 · 12 citations
    8. Dermatologic adverse events associated with chemotherapy and targeted anticancer therapy Dermatology Review · 2016 · 4 citations
    9. Cutaneous toxicities of cancer therapy 2002 · 114 citations
    10. Advances in the Management of Cutaneous Toxicities of Targeted Therapies Seminars in Oncology · 2012 · 42 citations
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