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    Did you mean Hand-Foot Syndrome?
    Glossary Hand-Foot Syndrome

    causes redness, swelling, and pain on palms and soles

    Hand-Foot Syndrome, also known as Palmar-Plantar Erythrodysesthesia (PPE), is a side effect of certain chemotherapy drugs. It causes redness, swelling, and pain on the palms of the hands and the soles of the feet, and in severe cases, can lead to blistering and peeling of the skin. This condition occurs because the chemotherapy drugs leak out of the capillaries in these areas, leading to inflammation and damage.

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    1. Pathogenesis of Hand-Foot Syndrome induced by PEG-modified liposomal Doxorubicin Human cell · 2013 · 63 citations
    2. Prophylaxis and Management of Skin Toxicities Breast care · 2019 · 15 citations
    3. Skin toxicity induced by chemotherapy or molecular targeted therapy combined with immune checkpoint inhibitors in Asian patients: A literature review by the Japanese Pharmacist-led Oncodermatology Study Team International Journal of Clinical Oncology · 2026
    4. Chemotherapy and the Skin: Understanding Dermatologic Side Effects Cureus · 2026
    5. Skin toxicity of anti‐cancer therapy Journal der Deutschen Dermatologischen Gesellschaft · 2008 · 19 citations
    6. Targeted Therapy– and Chemotherapy-Associated Skin Toxicities: Systematic Review and Meta-Analysis Oncology nursing forum · 2020 · 6 citations
    7. Deferasirox, an oral iron chelator, prevents hepatocarcinogenesis and adverse effects of sorafenib Journal of clinical biochemistry and nutrition · 2016 · 12 citations
    8. Dermatologic adverse events associated with chemotherapy and targeted anticancer therapy Dermatology Review · 2016 · 4 citations
    9. Cutaneous toxicities of cancer therapy 2002 · 114 citations
    10. Advances in the Management of Cutaneous Toxicities of Targeted Therapies Seminars in Oncology · 2012 · 42 citations
    11. The incidence and management of cutaneous adverse events of the epidermal growth factor receptor inhibitors Postępy Dermatologii i Alergologii · 2017 · 18 citations
    12. Cutaneous Adverse Events of Targeted Anticancer Therapy: A Review of Common Clinical Manifestations and Management DOAJ (DOAJ: Directory of Open Access Journals) · 2015 · 2 citations
    13. Dermatologic Side Effects of Systemic Targeted Anticancer Therapy Springer eBooks · 2018
    14. Cutaneous reactions to targeted therapies in children with CNS tumors: A cross‐sectional study Pediatric Blood & Cancer · 2019 · 16 citations
    15. Cutaneous toxicities of new targeted cancer therapies: must know for diagnosis, management, and patient-proxy empowerment Annals of palliative medicine · 2019 · 7 citations
    16. Chemotherapy and Cutaneous Drug Reactions Springer eBooks · 2015 · 1 citations
    17. Clinical development and management of adverse events associated with FGFR inhibitors Cell Reports Medicine · 2023 · 65 citations
    18. Cutaneous Drug Eruptions Associated with the Use of New Oncological Drugs 2012 · 29 citations
    19. DERMATOLOGICAL ADVERSE EFFECTS OF CHEMOTHERAPEUTIC AGENTS: EXPERIENCE FROM A TERTIARY CENTRE Journal of evolution of medical and dental sciences · 2017
    20. Effets secondaires cutanéo-muqueux des nouvelles molécules anticancéreuses: Inhibiteurs de l'EGF-R, inhibiteurs de tyrosine kinase et stabilisateurs du fuseau mitotique 2011
    21. Cutaneous adverse events to systemic antineoplastic therapies: a retrospective study in a public oncologic hospital Anais Brasileiros de Dermatologia · 2021 · 7 citations
    22. Cutaneous Reactions to Chemotherapeutic Agents ˜The œAmerican journal of the medical sciences · 2001 · 53 citations
    23. The risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients: a systematic review and meta-analysis Cutaneous and Ocular Toxicology · 2018 · 9 citations
    24. Topoisomerase‐Interacting Agents 2013 · 2 citations
    25. Cutaneous Adverse Events of Tyrosine Kinase Inhibitors in Endocrine Tumors: Clinical Features, Mechanisms, and Management Strategies Biomedicines · 2025
    26. Clinical Management of Cutaneous Adverse Events in Patients on Chemotherapy: A National Consensus Statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology 2019 · 12 citations
    27. Comparative Outcomes of Cutaneous Vesicostomy Versus Cystoscopic Valve Ablation in the Initial Management of Posterior Urethral Valves ARC Journal of Urology · 2025
    28. Prevention and management of dermatological toxicities related to anticancer agents: ESMO Clinical Practice Guidelines☆ Annals of Oncology · 2020 · 86 citations
    29. Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer Journal of the American Academy of Dermatology · 2014 · 88 citations
    30. Spotlight commentary: Navigating the cutaneous side effects of chemotherapy British Journal of Clinical Pharmacology · 2025