77 citations
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August 1986 in “Archives of Dermatology” This report describes a case in which intramuscular cyanocobalamin treatment reversed skin and nail pigmentation changes and premature gray hair caused by vitamin B12 deficiency due to pernicious anemia.
11 citations
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August 1986 in “Archives of Dermatology” This case report describes a patient with skin and nail hyperpigmentation and premature gray hair due to vitamin B12 deficiency, which were reversed after treatment with cyanocobalamin.
April 2019 in “Journal of the Endocrine Society” This case report suggests that a supplement containing biotin, beta carotene, vitamin C, zinc, and copper may improve insulin resistance markers and hair loss in a patient with non-classic 11-hydroxylase deficiency.
16 citations
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February 2008 in “PubMed” Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.
2 citations
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June 2023 in “Journal of the American Academy of Dermatology” This observational study using NHANES data from 2011 to 2020 found that the use of hair, skin, and nails supplements almost doubled, particularly among younger, female, Black, and Hispanic/Latino individuals, despite limited evidence on their efficacy and potential health risks.