60 citations
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October 2020 in “Journal of Controlled Release”
This study found that curcumin nanocrystals efficiently penetrated hair follicles down to the lower infundibulum in an ex-vivo pig ear model, regardless of the gel vehicle used, though passive dermal penetration varied with the vehicle’s skin hydrating properties.
11 citations
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April 2011 in “Biomolecules & Therapeutics”
This study found that finasteride-containing anionic liposomes enhanced skin retention and had moderate hair growth efficacy, suggesting potential for treating androgenetic alopecia with reduced systemic side effects.
7 citations
,
October 2024 in “Drug Delivery and Translational Research”
In this study, using an ex vivo porcine skin model, researchers found that a 4% nanoparticle concentration significantly enhanced the transport of fluorescein sodium into hair follicles compared to a 2% concentration, while higher concentrations did not further increase penetration depth.
The user switched from an alcohol-based Minoxidil to a non-alcohol variant with oleanolic acid due to scalp dryness. They are concerned if the non-alcohol variant will be less effective for hair growth.
The "crunching" sound during microneedling is likely the needles penetrating the scalp's outer layers, not cutting hair. Users suggest using a derma stamp instead of a roller to avoid potential hair damage.
Microneedling is unlikely to damage existing hair if done with a device using a smaller needle count, like a 9-needle cartridge, and a stamping motion. Hair follicles are deeper than the typical needle penetration depth.
A user is considering switching from oral to topical finasteride to reduce systemic DHT impact and is exploring ethossomal finasteride for better skin penetration and potential hair regrowth. They found ethossomal finasteride in Brazil and are seeking opinions on its effectiveness compared to other topical delivery methods.
Do you want finasteride to penetrate better? The ideal solvent to maximize its effect.Formulation sources describe propylene glycol and microemulsion vehicles as increasing how much topical finasteride crosses the skin, but better penetration has not been shown to mean better hair results, and it also raises systemic exposure. The vehicle and strength are decisions for a prescriber or compounding pharmacist.