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Research

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research Human Wharton’s Jelly Mesenchymal Stem Cells Plasticity Augments Scar-Free Skin Wound Healing with Hair Growth

102 citations , April 2014 in “PloS one”

In this study, Wharton’s Jelly Mesenchymal Stem Cells, cultured with human platelet lysate, showed enhanced wound-healing capabilities and multilineage differentiation potential, distinguishing them from bone marrow-derived stem cells and presenting exciting prospects for regenerative medicine.

research 1338 Epidermal growth factor receptor protects from immune privilege collapse and scarring hair follicle destruction

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study reported that in mouse models, deletion of EGFR resulted in stem cell hyper-proliferation followed by apoptosis, leading to scarring alopecia, and implicated EGFR's role in maintaining hair follicle quiescence and immune privilege during inflammation.

research Changes in the hair growth cycle in women with non-scarring alopecia

October 2018 in “Vestnik dermatologii i venerologii”

This study found that VEGF growth factor plays a significant role in the development of androgenetic alopecia and telogen hair loss in women, more so than KGF, TGF-01, or EGF.

research Efficacy of topical tofacitinib in promoting hair growth in non-scarring alopecia: possible mechanism via VEGF induction

27 citations , September 2017 in “Archives of Dermatological Research”

In this study, topical tofacitinib significantly increased hair regrowth in mice compared to minoxidil or vehicle, potentially due to elevated VEGF levels and reduced inflammation.

research ISID1338 - Epidermal growth factor receptor protects from immune privilege collapse and scarring hair follicle destruction

May 2023

This research observed that EGFR activity appears to maintain hair follicle quiescence and immune privilege, and its inhibition may lead to stem cell apoptosis and scarring alopecia during inflammation.

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Community Join

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community Is microneedling a risk if you want to have a hair transplant in the future?

in Transplants 13 upvotes 10 months ago

Microneedling may risk scarring, potentially complicating future hair transplants. Alternatives like tretinoin with minoxidil are suggested for better hair growth.

community Was scared to try fin and jumped straight to 2.5mg Dut?

36 upvotes 1 week ago

The user started with oral minoxidil and switched to 2.5mg dutasteride, experiencing significant hair growth without side effects. They believe dutasteride has fewer side effects than finasteride due to its action on both type 1 and 2 5-alpha reductase enzymes.

community Am I a Hyper Responder or is this Normal Growth

39 upvotes 1 year ago

The user experienced significant hair regrowth in 5 weeks using Minoxidil, Finasteride, Dutasteride, biotin, collagen, derma stamping, and a mixture of oils, leading others to label them a "hyper responder." Some users advised caution with microneedling frequency to avoid potential scarring.

community Scared of Twink death due to minoxidil

in Minoxidil 9 months ago

A 19-year-old is considering switching from topical to oral minoxidil to combat hair loss, despite concerns about increased body hair. They are currently using minoxidil, ketoconazole shampoo, and dutasteride, and are willing to accept the trade-off of more body hair for better scalp hair growth.

community The initial Minoxidil shed is scary af, but I'm sticking to it.

in Minoxidil 6 upvotes 1 year ago

The user started using minoxidil and a dermastamp after only using finasteride, experiencing initial hair shedding but noticing new hair growth. They are considering adding ketoconazole shampoo to their routine.

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Clinics

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Learn

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learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Stem Cell Factor

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn horsetail extract

How does horsetail extract support hair growth — is it the silica, the antioxidants, or both? Horsetail extract supports hair growth primarily through its silica content.

learn Vitamin E

What does Vitamin E do for hair growth and scalp health? Vitamin E supports scalp health and may promote hair growth through antioxidant properties.

learn Scalp Micropigmentation

scalp tattoos to mimic the appearance of light stubble

Can I use hair loss treatments (finasteride, minoxidil) after scalp micropigmentation? About half of clinics say finasteride can continue through scalp micropigmentation, and about half ask clients to pause topical minoxidil during the sessions and for roughly 30 days afterwards. That pause is clinic aftercare convention, not a label instruction - ask your prescriber first, because stopping minoxidil usually causes shedding.

learn capsicum

Can the heat from capsicum actually wake up dormant hair follicles? Capsicum heat may stimulate dormant hair follicles through increased blood flow and growth factors.
How does capsicum improve scalp circulation and boost growth? Capsaicin dilates blood vessels through TRPV1 activation, so capsicum is expected to raise scalp blood flow, but every human hair-loss study used it inside a multi-ingredient formula — and the strongest one gave it orally, not on the scalp — so its effect on hair by itself is unproven, and it is a known skin irritant.

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Experts

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Unscored
SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas