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research Abstract 3889: Cyclin-dependent kinase 4 levels affect the number of hair follicle stem cells in mouse epidermis

April 2010 in “Cancer Research”

This study found that altering CDK4 expression in mice affects the population of keratinocyte stem cells, suggesting a correlation with susceptibility to skin papillomas.

research Cervical cancer metastasis to the scalp presenting as alopecia neoplastica

24 citations , February 2007 in “International Journal of Dermatology”

This case report describes a 45-year-old Japanese woman with metastatic cervical cancer, including rare scalp metastases, who experienced severe scalp tenderness and patchy hair loss before her death.

research Distribution and number of epidermal growth factor receptors in skin is related to epithelial cell growth

124 citations , December 1983 in “Developmental Biology”

EGF receptors are crucial for skin cell growth and decrease with age.

research Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

1 citations , September 2012 in “Journal of Investigative Dermatology”

This study found that aging mice with an epidermal deletion of DNA methyltransferase 1 had a reduced number of hair follicles, due to decreased stem cell activation probability.

research Decreased lymphocyte reactivity and auto-immunity in alopecia areata

54 citations , August 1981 in “British Journal of Dermatology”

This study found that patients with alopecia areata had significantly lower T cell numbers and reduced lymphocyte responses compared to healthy controls, correlated with hair loss severity and presence of antithyroid antibodies.

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Community Join

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community THE HARSH REALITY OF THE HAIR FOLLICLE’s CYCLICAL LIFE? 6.5 months of treatment

in Progress Pictures 399 upvotes 1 year ago

A user shared their 6.5-month experience with topical finasteride (2%) and minoxidil (5%), noting initial progress followed by a significant shedding phase. Others in the conversation reassured that shedding is normal and suggested staying consistent with the treatment for potential regrowth.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

7 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community If PP405 works it will be fkn impossible to buy it.

103 upvotes 10 months ago

PP405 is a potential hair loss treatment that may activate dormant hair follicles, but there are concerns about its effectiveness, cost, and side effects. Users discuss treatments like minoxidil, finasteride, and RU58841, expressing skepticism about PP405's long-term success and accessibility.

community If we can clone a sheep why we can't cure baldness till now

in Research/Science 181 upvotes 1 year ago

Hair loss treatments like Minoxidil, finasteride, and stem cell therapies exist, but a complete cure is hindered by genetic complexity and market dynamics. Cloning hair follicles is considered a potential solution, but it's currently not feasible.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

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Learn

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learn Hair Transplant

Surgery that moves hair follicles from the back of the scalp to thinning areas

How many grafts do I need for a hair transplant? You typically need 1,000 to 7,000 grafts depending on hair loss extent and goals.
How many grafts are needed for an eyebrow transplant? Clinics quote anywhere from about 50 to 1,200 grafts for an eyebrow transplant; the number depends on the person and is set at consultation.

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Peppermint

herb and oil thought to stimulate skin and hair

learn Exosomes

Tiny cell-derived particles offered by clinics as an injectable treatment

learn Niacinamide

Does niacinamide support hair follicle nutrition? Niacinamide is a precursor of NAD+, a molecule cells use for energy. Whether it affects hair follicles in people has not been tested.

learn Scalp Micropigmentation

Will scalp micropigmentation damage my existing hair or follicles? Providers say SMP sits above the hair follicles and does not harm them. No study has tested this, and infection or scarring from any tattoo can affect the skin.

learn Sulforaphane

Can sulforaphane protect hair follicles from inflammation and damage? In lab and mouse studies, sulforaphane reduced markers of inflammation and oxidative stress. No human study has tested whether it protects hair follicles.

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Clinics

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Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas