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research 138 Characterization of xenobiotic metabolizing enzymes of a reconstructed human epidermal model from adult hair follicles

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, the reconstructed skin epidermal model derived from hair follicles showed gene expression and enzyme functionality consistent with native human skin, suggesting its viability for studying skin metabolism and potential toxicity of dermo-cosmetic ingredients.

research The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles

September 2025 in “Science Advances”

This study reports that PADI4, an enzyme involved in posttranslational protein modifications, regulates progenitor cell transitions in hair follicle development by repressing transcription and interacting with translational and ribosomal processes.

Oral Minoxidil Bio-Activation by Hair Follicle Outer Root Sheath Cell Sulfotransferase Enzymes Predicts Clinical Efficacy in Female Pattern Hair Loss

research Oral minoxidil bio‐activation by hair follicle outer root sheath cell sulfotransferase enzymes predicts clinical efficacy in female pattern hair loss

9 citations , August 2019 in “Journal of The European Academy of Dermatology and Venereology”

Minoxidil activation by hair enzymes predicts treatment success for female hair loss.

research The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z‐protein in cells of the bulge region

5 citations , July 1999 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

The researchers reported that applying proteolytic enzymes to mice skin negatively affected hair follicles, leading to degeneration and potential impairment of stem cells from the bulge area.

research The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z-protein in cells of the bulge region

2 citations , July 1999 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

In this study, proteolytic enzymes applied to mice skin caused severe degeneration in hair follicles, including detachment of stem cells from their niche, suggesting potential impairment of stem cell function.

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Community Join

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community 5ar Type I in the frontal hair follicles - Dutasteride

in Finasteride/Dutasteride 21 upvotes 2 years ago

The conversation discusses that dutasteride may be more effective than finasteride for frontal hair loss due to higher 5ar Type 1 enzyme activity in that area. Some users question the validity of this information, while others confirm it with additional sources.

community Isn't it kind of strange that hair loss happens at where the 2 main superficial temporal arterty branches (temples and crown) are?

5 upvotes 3 years ago

Hair loss may be linked to blood flow and inflammation, with treatments like Minoxidil, finasteride, and quercetin being discussed. The conversation also mentions the role of 5AR enzyme distribution in hair follicles.

community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1391 upvotes 1 year ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

community Update about Hair Follicle Glucose Metabolism: New Clinical Data Collection with Ex-President Of American Board Of Hair Restoration Surgery.

39 upvotes 2 years ago

David Barreto shared that a London-based research group is conducting a 12-month trial for a new nutraceutical treatment for pattern hair loss, designed with Dr. Carlos Puig. The trial aims to provide robust data, with results expected in 1-2 years, potentially representing a significant advancement since finasteride’s introduction in 1997.

community Did anybody use beta sisterol for hair loss? I saw in many articles in the internet that said that beta sisterol blocks dht by inhibiting 5a reductase type 2 enzyme and some reviews of people who said that it worked better than saw palmetto in terms of stoping hair loss and helping prostate.

in Research/Science 9 upvotes 3 years ago

Beta-sitosterol may inhibit 5-alpha reductase type 2 enzyme, potentially reducing DHT levels and promoting hair growth, similar to finasteride but possibly with fewer side effects. Its effectiveness and side effects compared to other treatments like saw palmetto and finasteride remain uncertain due to limited research.

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Learn

9 / 66 results

learn Baricitinib

JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

What role does Osteopontin play in protecting and repairing hair follicles? Osteopontin protects and repairs hair follicles by signaling cells to survive and recover.

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn Tretinoin

the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

learn Niacinamide

How does Niacinamide support the hair follicle’s nutrition? Niacinamide nourishes hair follicles by boosting energy production and supporting antioxidant defenses.

learn oleic acid

How does Oleic Acid support hair follicle strength and growth? Oleic acid strengthens hair follicles by enhancing hydration and reducing inflammation.

learn zinc PCA

Why is zinc important for preventing hair loss and supporting hair follicle function? Zinc is crucial for hair follicle health, supporting growth and repair processes.

learn Scalp Micropigmentation

Will scalp micropigmentation damage my existing hair or follicles? Scalp micropigmentation does not damage existing hair or follicles.

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas