April 2023 in “Rossijskij žurnal kožnyh i veneričeskih boleznej”
This collection presents a photogallery on the follicular occlusion syndrome, uniting diseases like hidradenitis suppurativa under shared pathogenesis, but reports no new clinical results.
156 citations
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October 2012 in “Seminars in Cell & Developmental Biology”
This study found that hairfollicle stem cells initially contribute to wound re-epithelialization, but long-lasting epidermal cells are primarily derived from a stem cell population in the isthmus portion of hairfollicles.
9 citations
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September 2013 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”
In this study, researchers found that the matriptase-HGF-c-MET pathway may be activated in proliferative cells of human hairfollicles and sebaceous glands, suggesting a potential role in hair growth regulation.
This review revisits mechanisms underlying acne lesion formation and suggests that preventing comedone development requires controlling critical factors in the pilosebaceous follicle before acne involvement.
52 citations
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May 2003 in “The journal of investigative dermatology/Journal of investigative dermatology”
This study found that overexpression of parathyroid hormone-related protein in mice resulted in 30–40% shorter hair due to premature transition into the catagen phase of the hair cycle.
Hairfollicle stem cells remain in bald individuals, but progenitor cells do not, raising questions about hair regrowth claims by Pelage. PP405 is discussed as a potential treatment, with skepticism about its effectiveness compared to existing treatments like Minoxidil and Finasteride.
Hairfollicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.
The conversation discusses using hairfollicle dermal papilla exosomes for hair loss treatment. It inquires about purchasing options for this treatment.
Hairfollicle cloning is claimed to be possible but not widely available due to potential safety issues, such as cancer risks. Current treatments like finasteride and dutasteride are not effective for everyone, and there is frustration over limited access to these medications.
Hairfollicle regeneration through stem cell rearrangement is discussed, focusing on bioengineered cellular structures rather than traditional hair transplants. Treatments mentioned include Minoxidil, finasteride, and RU58841.
Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.