185 citations
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January 2010 in “Experimental Dermatology” This study introduces the concept of a "gut–brain–skin axis" where ingesting a specific Lactobacillus strain in mice may reduce stress-induced skin inflammation and hair growth inhibition.
3 citations
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January 2017 in “Chinese Science Bulletin (Chinese Version)” This review discusses the gut-brain-skin axis and its role in skin diseases, advocating for treatments that integrate gut microbiota, mental health, and dietary interventions, but reports no new clinical results.
2 citations
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January 2018 in “Elsevier eBooks” This review discusses the complex mechanisms behind acne vulgaris and suggests that dietary modification, along with pro- and prebiotics, may influence its pathogenesis by addressing stress-induced skin inflammation.
February 2026 in “Frontiers in Immunology” This review highlights the role of the brain–gut–skin axis in systemic inflammatory skin conditions, revealing potential interventions like microbiome-directed treatments and integrative therapies, though emphasizes the need for more robust clinical validation.
In this narrative hypothesis-driven overview, the authors propose reframing rosacea as a neuroimmune disorder, highlighting the interconnected role of the skin-gut-brain axis, particularly central nervous system involvement alongside gut microbiota and neurogenic inflammation, to emphasize the need for multidisciplinary therapeutic approaches.