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research Transglutaminase from Hair Follicle of Guinea Pig

103 citations , February 1972 in “Proceedings of the National Academy of Sciences”

This study found that a unique transglutaminase in guinea pig hair-follicles, distinct from liver transglutaminase, likely plays a role in forming protein cross-links via ε(γ-glutamyl)lysine bonds.

research Kinetic Studies with Transglutaminases

91 citations , May 1972 in “Journal of Biological Chemistry”

This research found that the transfer reaction catalyzed by human plasma and guinea pig hair follicle transglutaminases aligns with a ping-pong mechanism involving peptide-bound glutamine.

research The deduced sequence of the novel protransglutaminase E (TGase3) of human and mouse

118 citations , June 1993 in “Journal of Biological Chemistry”

This study found that mouse and human protransglutaminase 3 enzymes require calcium-regulated activation for their role in later stages of cell envelope formation in the epidermis and hair follicle.

research Trichohyalin, an intermediate filament-associated protein of the hair follicle.

116 citations , April 1986 in “The journal of cell biology/The Journal of cell biology”

This study reports that a 190,000 molecular weight protein, identified as trichohyalin, may play a matrix role in the development of inner root sheaths in hair follicles.

research Hair Follicle Transglutaminases and the Formation of ε-(γ-Glutamyl) Cross-links

January 1981

In this study, researchers found that follicular and epidermal transglutaminases are biochemically and immunologically distinct, suggesting the possibility of selectively modifying hair or epidermal proteins.

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community What Norwood is this guinea pig and what’s bro’s stack?

2174 upvotes 4 months ago

The conversation humorously discusses a guinea pig's hair care routine and its perceived resistance to hair loss, contrasting it with human hair loss treatments like Minoxidil. Users joke about the guinea pig's hair being ideal for transplants and express envy over its fluffy appearance.

community Innovative hair loss treatment can restore 90% of lost hair

890 upvotes 2 years ago

A new hair loss treatment using dermal exosomes can restore up to 90% of lost hair in mice. Users discuss potential human trials and compare it to Minoxidil and Finasteride.

community Update July 2025] Most Promising Hair Loss Treatments in Clinical Trials

in Research/Science 267 upvotes 1 year ago

Promising hair loss treatments in clinical trials include Pyrilutamide, GT20029, CB-03-01, and PP405, with potential market releases between 2027 and 2029. Hair cloning remains experimental and expensive, while existing treatments like finasteride, minoxidil, and microneedling continue to be used.

community Great News! Hair Growth Treatment will be smooth in the future

in Research/Science 179 upvotes 10 months ago

Oleic acid, microneedling, and emu oil are discussed as potential hair growth treatments, with some users expressing skepticism about their effectiveness. Minoxidil and finasteride are recommended as current reliable treatments until more proven solutions are available.

community Has anyone used verteporfin + microneedling?

10 upvotes 2 years ago

A user is considering using verteporfin with microneedling, oral/topical minoxidil, and RU58841 to treat hair loss. They seek advice on dosage and application methods.

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