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GlossaryGremlin

protein inhibiting bone morphogenetic proteins, affecting hair growth

Gremlin is a protein that acts as an antagonist to bone morphogenetic proteins (BMPs), which are involved in various cellular processes including hair follicle development and growth. By inhibiting BMPs, Gremlin can influence hair growth cycles and has been studied for its potential role in conditions like alopecia, where hair loss occurs.

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research Niche formed by bone morphogenetic protein antagonists gremlin 1 and gremlin 2 in human hair follicles

5 citations , January 2022 in “Health Science Reports”

Gremlin proteins help regulate hair growth by balancing signals in hair follicles.

research Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles

11 citations , January 2018 in “Acta dermato-venereologica”

Researchers found specific genes in the part of hair follicles that could help treat hair disorders.

research Metformin Effects on Blood Levels of Gremlin-1 in Polycystic Ovarian Women

April 2023 in “PubMed”

Metformin lowers gremlin-1 and improves insulin resistance in women with PCOS.

research Colon Cancer Stem Cells: Promise of Targeted Therapy

411 citations , April 2010 in “Gastroenterology”

Targeting colon cancer stem cells might lead to better treatment results.

Integration Analysis of Transcriptome Sequencing and Whole-Genome Resequencing Reveals Wool Quality-Associated Key Genes in Zhexi Angora Rabbits

research Integration Analysis of Transcriptome Sequencing and Whole-Genome Resequencing Reveals Wool Quality-Associated Key Genes in Zhexi Angora Rabbits

December 2024 in “Veterinary Sciences”

Key genes and pathways improve wool quality in Zhexi Angora rabbits.

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community Finasteride and “anti-aging” effects

in Treatment 218 upvotes 2 months ago

Finasteride may help users look younger by suppressing DHT, affecting skin and hair. Users also emphasize skincare, sunscreen, and lifestyle for maintaining a youthful appearance.

community If RU58841 is such an effective anti androgen

in Research/Science 46 upvotes 1 year ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

community High DHT with finasteride. Help!

in Finasteride/Dutasteride 6 upvotes 1 year ago

Despite using 5% minoxidil, 0.1% finasteride, and other treatments like microneedling, MK-677, and Cialis, hair loss continues with high testosterone and DHT levels. Considering oral dutasteride but concerned about further increasing testosterone levels.