TLDR Metformin lowers gremlin-1 and improves insulin resistance in women with PCOS.
The study investigated the effects of metformin on blood levels of gremlin-1 in women with polycystic ovary syndrome (PCOS). Sixty PCOS patients and 30 healthy controls were included. PCOS patients exhibited higher levels of gremlin-1, blood glucose, insulin, and HOMA-IR compared to controls. After taking metformin (850 mg twice daily), there was a significant reduction in gremlin-1 levels, body mass index, blood glucose, insulin, and HOMA-IR in PCOS patients. The findings suggest that metformin effectively decreases gremlin-1 and improves insulin resistance in women with PCOS.
June 2003 in “Obstetrical & Gynecological Survey” After chemotherapy for a gestational trophoblastic tumor, normal pregnancy rates are possible, but there's a slightly higher risk of the tumor reoccurring in future pregnancies.
June 2003 in “Obstetrical & Gynecological Survey” Postmenopausal ovary stromal cells have a unique makeup and limited steroid production, suggesting androgens come from the adrenal gland.
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August 2022 in “Frontiers in Immunology” Fibroblasts are important in healing diabetic wounds, but high sugar levels can harm their function and slow down the healing process.
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February 2024 in “The Journal of Experimental Medicine” CXCL12+ fibroblasts help recruit neutrophils to fight skin infections.
May 2019 in “Paediatrics and child health” The document concludes that personalized treatment, including lifestyle changes and medication, is essential for managing PCOS in teenagers, while also addressing their psychological well-being.
