Gremlin-1 Level in Polycystic Ovary Syndrome and Its Clinical Correlations: A Case Control Study

    May 2023 in “ Journal of Pakistan Medical Association ”
    Aly M. Abdel-Karim, Ahmed Y. Rezk, Nahla A Nosair, Mostafa Farag Ellakany, Amira Fathy
    Image
    Studysummary This study found that women with polycystic ovary syndrome had significantly higher levels of serum and follicular fluid Gremlin-1 compared to healthy controls, suggesting potential diagnostic utility for these biomarker levels. Our plain-language summary of this paper — not a Tressless recommendation.
    The study conducted at Kafrelsheikh University Hospital, Egypt, from September 2021 to February 2022, involved 90 subjects, 45 of whom were patients with polycystic ovary syndrome (PCOS) and 45 were healthy controls. The study found that serum and follicular fluid Gremlin-1 levels were significantly higher in the patient group. The best cutoff of serum Gremlin-1 in the diagnosis of PCOS was ≥1.325ng/ml with an overall accuracy of 81.1%. The best cutoff of follicular fluid Gremlin-1 in the diagnosis of PCOS was ≥1.725ng/ml with an overall accuracy of 71.1%. The study concluded that there was a strong correlation between serum and follicular Gremlin-1 levels in PCOS patients.
    Discuss this study in the Community →