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A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity

research A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity

91 citations, May 2005 in “The Journal of Clinical Endocrinology & Metabolism”

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

Recent Advances in the Molecular Mechanisms Determining Tissue Sensitivity to Glucocorticoids: Novel Mutations, Circadian Rhythm, and Ligand-Induced Repression of the Human Glucocorticoid Receptor

research Recent Advances in the Molecular Mechanisms Determining Tissue Sensitivity to Glucocorticoids: Novel Mutations, Circadian Rhythm, and Ligand-Induced Repression of the Human Glucocorticoid Receptor

62 citations, August 2014 in “BMC Endocrine Disorders”

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

research Modulation of Glucocorticoid Action and the Treatment of Type-2 Diabetes

54 citations, December 2007 in “Best Practice & Research Clinical Endocrinology & Metabolism”

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

research Spatiotemporal Control of CRISPR/Cas9 Gene Editing

51 citations, June 2021 in “Signal Transduction and Targeted Therapy”

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

research 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Type 2 Diabetes

43 citations, August 2010 in “Expert Opinion on Investigational Drugs”

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community We Need A Solution For The Inflammatory Response related To AGA

in Research/Science 16 upvotes 3 months ago

The conversation is about finding a solution for scalp inflammation related to AGA, with the user expressing frustration that Minoxidil and Finasteride do not address inflammation. The user has researched glucocorticoids and topical NSAIDs for reducing inflammation and seeks advice from specialists.

community Pyrilutamide is working but not strong enough, how long should i wait for noticeable results?

in Update 3 upvotes 1 year ago

User discusses Pyrilutamide's effectiveness for hair loss, needing more time for results. Others suggest waiting 6-12 months and ask about side effects.

community AA and Hirsutism but T levels are normal

in Female 8 upvotes 3 years ago

27-year-old female experiences aggressive hair thinning and hirsutism despite normal testosterone levels. Spironolactone and 2% minoxidil were ineffective; high DHEA sulfate levels may be the cause.

community No luck with meds, Check your Cortisol.

in Treatment 34 upvotes 4 months ago

Cortisol from stress can cause hair loss. Controlling cortisol levels improved the effectiveness of finasteride for hair regrowth.

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