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GlossaryGLI1 (Glioma-associated oncogene homolog 1)

gene involved in cell growth and development signaling

GLI1, or Glioma-associated oncogene homolog 1, is a gene that encodes a protein involved in the Hedgehog signaling pathway, which is crucial for cell growth and development. Abnormal activation of GLI1 can lead to uncontrolled cell proliferation and is associated with various cancers, including gliomas.

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Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

research Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

14 citations, June 2018 in “Frontiers in pharmacology”

Green tea compound EGCG helps mink hair follicles grow by affecting certain cell growth pathways.

research Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors

136 citations, April 2013 in “Clinical Cancer Research”

The drug IPI-926 is safe at 160 mg daily and may help treat certain tumors, especially basal cell carcinoma.

research Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened

63 citations, May 2011 in “Clinical cancer research”

The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.

research Keratin 17 in Disease Pathogenesis: From Cancer to Dermatoses

62 citations, October 2018 in “Journal of pathology”

Keratin 17 is linked to various diseases, including cancer and skin conditions, and may be a target for diagnosis and treatment.

research p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis

19 citations, December 2015 in “Journal of Investigative Dermatology”

The protein p53 directly reduces the production of Keratin 17, a skin and hair protein, in rats with radiation dermatitis.

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