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GlossaryGlial Cell Line-Derived Neurotrophic Factor

promotes neuron survival and growth, especially dopamine-producing ones

Glial Cell Line-Derived Neurotrophic Factor (GDNF) is a protein that promotes the survival and growth of neurons, the cells responsible for transmitting information in the nervous system. It is particularly important for the maintenance and repair of certain types of neurons, including those that produce dopamine, which are crucial for motor control and are affected in diseases like Parkinson's.

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research GDNF Promotes Hair Formation and Cutaneous Wound Healing by Targeting Bulge Stem Cells

7 citations, June 2020 in “npj regenerative medicine”

GDNF helps grow hair and heal skin wounds by acting on hair stem cells.

research Age-Associated Decrease in GDNF and Its Cognate Receptor GFRα-1 Protein Expression in Human Skin

2 citations, June 2016 in “International journal of experimental pathology”

Human skin has less GDNF and its receptor with age.

research Reawakening GDNF's Regenerative Past in Mice and Humans

1 citations, April 2022 in “Regenerative Therapy”

Activating the GDNF-GFRα1-RET signaling pathway could potentially promote skin and limb regeneration in humans and could be used to treat hair loss and promote wound healing.

research The Impact of Growth Factors in Platelet-Rich Plasma Combination Therapy for Androgenic Alopecia

January 2024 in “Dermatologic Therapy”

PRP therapy with specific growth factors improves hair density and thickness in androgenic alopecia.

research Faculty Opinions Recommendation of GDNF Promotes Hair Formation and Cutaneous Wound Healing by Targeting Bulge Stem Cells

January 2021 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

GDNF helps grow hair and heal skin wounds by acting on specific stem cells.

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community Please explain this Minoxidil phenomena

in Minoxidil 58 upvotes 1 year ago

The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.