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research Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice

22 citations , August 2013 in “Experimental Dermatology”

In this study, the researchers found that constitutive activation of the EGFR in mice led to increased sebum production, enlarged sebaceous glands, and altered gene expression related to sebocyte proliferation and lipogenesis.

research 1434 Epithelially derived MPZL3 negatively regulates murine and human sebaceous gland size and sebocyte proliferation

April 2023 in “Journal of Investigative Dermatology”

This study found that MPZL3 plays a crucial role in controlling sebaceous gland size and sebocyte proliferation in mice and humans, implicating its potential involvement in skin disorders like acne and psoriasis.

research 548 Deletion of Myelin Protein Zero-like 3 increases sebaceous gland size and sebocyte proliferation but reduces skin adipose depots: Can MPZL3 inhibition promote excessive loss of lipids via sebum hypersecretion?

November 2022 in “Journal of Investigative Dermatology”

This study found that MPZL3 knockout mice showed reduced dermal white adipose tissue and increased sebocyte proliferation, suggesting a regulatory role for MPZL3 in lipid metabolism balance between adipocytes and sebocytes.

research 724 MPZL3 functions as a negative regulator of sebaceous gland size and sebocyte proliferation

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study indicates that MPZL3 negatively regulates sebaceous gland size in mice by controlling sebocyte proliferation, with implications for disorders like acne and psoriasis.

research A cross-sectional observational study showing sebaceous glands differences between psoriatic alopecia and alopecia areata

2 citations , February 2024 in “JAAD International”

Sebaceous gland maturity and size differ between psoriatic alopecia and alopecia areata.

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community Finasteride and Eye Problems: You’re Not Going Crazy

in Finasteride/Dutasteride 503 upvotes 1 year ago

Finasteride can cause dry eyes and vision issues due to its impact on the meibomian glands. Users have mixed experiences, with some experiencing eye discomfort and others having no side effects.

community Got Gynecomastia from Dutasteride, now what?

7 upvotes 2 weeks ago

The user experienced gynecomastia after switching from finasteride to dutasteride and is considering stopping dutasteride or having surgery to remove the gland. They are advised to stop dutasteride, consider surgery, and explore medications like raloxifene or tamoxifen to manage symptoms.

community Recovery in 3 months; May to September 2026

24 upvotes 1 week ago

A 20-year-old experienced significant hair recovery in three months using a combination of topical and oral minoxidil, along with finasteride and multivitamins. Initial side effects included a perceived increase in breast size and reduced libido, but these resolved, and the user is pleased with the progress.

community No results for 1 year till I tried this.

8 upvotes 4 years ago

The user saw no hair loss improvement for a year using 1mg finasteride and 5% minoxidil. They experienced better results after reducing finasteride to 0.25mg, adding a derma pen treatment, and applying a solution with minoxidil and melatonin.

community Switched to DUT from Fin after 30 months of no progress

161 upvotes 1 month ago

The user switched from finasteride to dutasteride after 30 months with no progress, experiencing a significant shed initially. The current treatment includes daily dutasteride, oral minoxidil, topical finasteride and minoxidil, derma stamping, PRP, and calecim exosomes.

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learn Epidermal Growth Factor

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