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GlossaryGenotype-Phenotype Correlations

relationship between genes and observable traits

Genotype-Phenotype Correlations refer to the relationship between an individual's genetic makeup (genotype) and their observable traits (phenotype). For example, in the context of hair, certain genotypes might be linked to traits like hair color, texture, or susceptibility to conditions like alopecia. Understanding these correlations helps scientists predict how genetic variations can manifest as physical characteristics or health conditions.

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research Ichthyosis Follicularis With Atrichia And Photophobia (IFAP) Syndrome: A Study On Genetic Mutation In A Japanese Patient

January 2011 in “Journal of Human Genetics”

A Japanese patient with a rare genetic disorder had a less severe case than others, suggesting other factors may affect symptoms.

research Cutaneous Manifestations in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy: A Comprehensive Review

January 2024 in “Biomedicines”

The review shows that skin symptoms like chronic fungal infections, hair loss, and skin depigmentation are key for early detection and management of APECED.

research Abstracts

2 citations , January 2019 in “Medizinische Genetik”

The document reports findings on genetic research, including ethical concerns about genome editing, improved diagnosis of mitochondrial mutations, solving inherited eye diseases, confirming gene roles in epilepsy, linking a gene to aneurysms, and identifying genes associated with age-related macular degeneration.

Phenotypic Heterogeneity in Human Genetic Diseases: Ultrasensitivity-Mediated Threshold Effects as a Unifying Molecular Mechanism

research Phenotypic Heterogeneity in Human Genetic Diseases: Ultrasensitivity-Mediated Threshold Effects as a Unifying Molecular Mechanism

July 2023 in “Journal of Biomedical Science”

Different people show different symptoms for genetic diseases because of how sensitive their bodies are to small changes in important factors.

research Regulatory Mutations in TBX3 Disrupt Asymmetric Hair Pigmentation That Underlies Dun Camouflage Color in Horses

73 citations , December 2015 in “Nature Genetics”

Mutations in TBX3 cause horses to have more even hair color instead of Dun camouflage.

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community Using 23andme to insight minoxidil response / SULT1A1 activity

in Minoxidil 10 upvotes 4 years ago

The conversation discusses using 23andme to determine if someone might respond well to minoxidil for hair loss treatment, and mentions the user's personal experience with micro-needling and minoxidil.

community Dutasteride: More Than a DHT Reducer – A Potential Androgen Receptor Inhibitor?

in Finasteride/Dutasteride 31 upvotes 11 months ago

Dutasteride may inhibit androgen receptors in addition to reducing DHT, potentially explaining its effectiveness over finasteride for hair loss. Concerns about its impact on muscle growth are debated, with some suggesting no significant effects.

community Minoxidil works only with Retinoic acid

in Minoxidil 316 upvotes 5 months ago

Minoxidil is more effective when combined with retinoic acid, such as tretinoin or tazarotene, enhancing hair growth. Some users experience significant regrowth, while others see minimal effects or side effects.

community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

in Treatment 6 upvotes 9 months ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community Why do so many people trash on finasteride?

in Chat 247 upvotes 10 months ago

Finasteride is effective for hair regrowth, especially on the crown, but can cause side effects like reduced libido and erectile dysfunction in some users. Opinions are mixed, with some reporting positive results without side effects and others experiencing significant issues.

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