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Glossary Genetic Hair Disorders

conditions affecting hair growth or health inherited through genes

Genetic Hair Disorders, also known as Hereditary Hair Disorders, are conditions affecting hair growth, structure, or health that are passed down through families via genes. These disorders can lead to various issues such as hair thinning, baldness (alopecia), or abnormal hair texture, and are often diagnosed through family history and genetic testing.

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Research

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research To grow or not to grow: Hair morphogenesis and human genetic hair disorders

43 citations , December 2013 in “Seminars in Cell & Developmental Biology”

This mini-review discusses human hair follicle development and summarizes genetic disorders linked to abnormalities in hair follicle morphogenesis, structure, or regeneration, but reports no new experimental results.

research Genetic Hair Disorders: A Review

26 citations , July 2019 in “Dermatology and Therapy”

This article discusses genetic hair disorders in children, outlining diagnostic approaches and highlighting the significance of distinguishing isolated hair defects from those associated with syndromes, but it reports no new clinical results.

research Polarized microscopy in genetic hair disorders: case series

January 2025

This study utilized polarized light microscopy to examine hair shafts in ten children with rare genetic disorders, such as Netherton syndrome and ectodermal dysplasia, providing valuable diagnostic insights into hair thickness, composition, and structural irregularities associated with these conditions.

research The genetics of hair shaft disorders

59 citations , June 2008 in “Journal of The American Academy of Dermatology”

This article reviews major types of genetic hair shaft defects and associated syndromes, emphasizing understanding histologic features and diagnostic methods, but reports no new clinical findings.

research Genetic hair and nail disorders

37 citations , January 2005 in “Clinics in dermatology”

This review discusses recent advances in understanding the genetics of hair and nail disorders and reports no new clinical results.

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Community Join

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community Female diffuse hair loss on spiro with irregular periods (photos) + genetic hair loss

in Female 16 upvotes 1 year ago

A 34-year-old woman is experiencing diffuse hair loss and irregular periods, possibly due to long-term spironolactone use. She is considering minoxidil and finasteride for treatment and seeking medical advice for androgenic alopecia and hormonal imbalances.

community Hair Loss Causes Depression. Not Finasteride.

187 upvotes 7 months ago

Finasteride and Dutasteride do not cause depression or mood disorders; hair loss itself may be a more significant factor. Some users experience side effects from Finasteride, but it is generally well-tolerated.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

140 upvotes 11 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community DUPA, Non Responders and Connective Tissue Disorders

8 upvotes 1 year ago

A 27-year-old male with diffuse hair loss, including the donor area, did not respond to finasteride, dutasteride, or minoxidil. He suspects his hair loss may be linked to a mild connective tissue disorder, possibly affecting the structural support of hair follicles, rather than being purely hormonal.

community Hair Loss & Lipids: Why you have sebderm, folliculitis, LPP, inflammation, etc...

131 upvotes 1 year ago

Excess sebum rich in cholesterol and triglycerides can lead to hair loss through inflammation, with treatments like Ciclopirox shampoo, Benzoyl Peroxide shampoo, and Clindamycin gel recommended for managing conditions like seborrheic dermatitis and folliculitis. Pioglitazone is suggested for Lichen Planopilaris, while Omega-3s and reducing processed foods may improve sebum quality, though genetic factors play a significant role.

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Learn

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learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Overview

learn Stem Cell Factor

learn Vitamin B1

Thinning hair over time? It might not just be genetics: lack of B1 and B2 could be silently working against you. There is no verified human trial showing that B1 or B2 deficiency causes thinning hair or that correcting it regrows hair; a 2019 review concludes the role of micronutrients in hair loss is real but unclear and still needs controlled trials.

learn Hair Transplant

What causes hair loss in women that may lead to considering a hair transplant? Genetic factors, hormonal changes, stress, and nutritional deficiencies often cause hair loss in women.
What causes male pattern baldness? Male pattern baldness is caused by genetic sensitivity to the hormone DHT.
What is male pattern baldness? Male pattern baldness is a genetic condition causing hair loss in men, starting with a receding hairline.

learn TDM-105795

What types of alopecia or hair loss conditions might TDM-105795 be designed to target based on current research? TDM-105795 may target non-scarring alopecia, particularly androgenetic alopecia.

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Clinics

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Trichology
The Pharmacy for Hair Loss & Scalp Disorders, PLLC.Brentwood, TN · US

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