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research Gene-Environment Interaction Between CYP1B1 and Oral Contraception on Frontal Fibrosing Alopecia

May 2024 in “JAMA Dermatology”

In this study, researchers identified genetic factors associated with frontal fibrosing alopecia, noting a protective effect of a specific CYP1B1 gene variant, which may offer insights into the disease's pathogenesis and future risk mitigation strategies.

research A Missense Mutation in the Cadherin Interaction Site of The Desmoglein 4 Gene Underlies Localized Autosomal Recessive Hypotrichosis

33 citations , October 2005 in “Journal of Investigative Dermatology”

A specific gene mutation causes sparse, brittle hair in a family.

research Fgf21 Deficiency Delays Hair Follicle Cycling and Modulates miRNA–Target Gene Interactions in Mice

May 2025 in “Biology”

In this study, researchers found that Fgf21 knockout mice exhibited delayed hair follicle cycling compared to wild-type mice, potentially due to altered miRNA interactions affecting Vezf1 and Map3k1 expression, providing insights into the molecular regulation of hair growth.

research Neuropsychiatric Adverse Events of Montelukast: An Analysis of Real-World Datasets and drug−gene Interaction Network

26 citations , December 2021 in “Frontiers in Pharmacology”

This study found a significant association between montelukast and increased reports of neuropsychiatric adverse events, including suicidal ideation and depression, in the FAERS database.

research Adverse events associated with aromatase inhibitors: an analysis of real-world datasets and drug-gene interaction network

1 citations , November 2024 in “Expert Opinion on Drug Safety”

In this retrospective pharmacovigilance study, researchers analyzed over 7,900 adverse event reports related to aromatase inhibitors, identifying common side effects and toxicological mechanisms to highlight potential safety concerns in treating postmenopausal hormone receptor-positive breast cancer.

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Community Join

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community Finasteride 0.5/1 pill a day + 3-5g Creatine Daily

4 upvotes 4 years ago

A 22-year-old is considering using finasteride daily with 3-5g of creatine to manage hair loss and reduce finasteride side effects. Users discuss the potential impact of creatine on DHT levels and its interaction with finasteride.

community 5 months topical spiro + minox + micro

6 upvotes 1 year ago

A 35-year-old male uses topical minoxidil, spironolactone, and microneedling for hair loss, with spironolactone prescribed based on a DNA test indicating poor response to finasteride and dutasteride. Despite concerns about the test's validity and spironolactone's side effects, he reports stable or improved hair condition and no low testosterone symptoms.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 58 upvotes 1 year ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community Journey against alopecia - Finasteride 3 month

17 upvotes 5 years ago

A 26-year-old man from France started experiencing hair loss in September 2020 and began using finasteride in June 2021, reporting some improvement after three months without side effects. He plans to continue finasteride for a year before considering additional treatments like minoxidil or dermarolling.

community Breezula phase 3 results said to be released next month

26 upvotes 1 year ago

Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

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Learn

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learn Vascular Endothelial Growth Factor

Are there risks or side effects associated with treatments that increase Vascular Endothelial Growth Factor (VEGF)? In a VEGF gene-therapy trial for leg artery disease, raising VEGF caused more leg swelling, and excess VEGF drives leaky, abnormal vessels in mice and in eye disease. No long-term studies have tested the safety of treatments that raise VEGF in the scalp.

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Clinics

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Hair Loss Treatments
Gene Lee Skin ClinicSan Diego, CA · US

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