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research Publicly Available Large Language Models for Trichoscopy: A Head-to-Head Comparison with Dermatologists

January 2026 in “Diagnostics”

This study reports that publicly available large language models are currently less accurate than human experts in diagnosing trichoscopic images, suggesting the need for further development and specialized training for these AI tools in trichology.

research Artificial Intelligence in Patient Education for Androgenetic Alopecia: A Comparative Study of ChatGPT, Gemini, and Deepseek R1

October 2025 in “Dermatology Practical & Conceptual”

This study found that ChatGPT 4.0 and Gemini 1.5 Flash provided more accurate and user-friendly responses to androgenetic alopecia questions than Deepseek R1, suggesting they could be effective tools for patient education with physician guidance.

Synthesis of Spiro[cyclohexane-1,2'-[2H]indene] Derivatives as Inhibitors of Steroid 5α-Reductase

research Synthesis of Spiro[cyclohexane-1,2?-[2H]indene] derivatives as inhibitors of steroid 5?-reductase

8 citations , June 1995 in “Helvetica Chimica Acta”

This article outlines the synthesis of spiro[cyclohexane‐1,2′‐[2 H ]indene] derivatives similar to known steroid 5α‐reductase inhibitors, but it does not report experimental findings.

research Synthesis and biological evaluation of esters of 16-formyl-17-methoxy-dehydroepiandrosterone derivatives as inhibitors of 5α-reductase type 2

5 citations , November 2015 in “Journal of Enzyme Inhibition and Medicinal Chemistry”

This study found that aliphatic ester moieties in 16-formyl-17-methoxy dehydroepiandrosterone derivatives increased their potency as 5α-reductase type 2 inhibitors in vitro compared to finasteride.

Essential Oils-Based Nanoemulsion Formulation Boosts Hair Growth in C57BL/6 Mice Compared to Minoxidil 2%

research Essential oils-based nanoemulsion formulation boosts hair growth in C57BL/6 mice as compared to minoxidil 2%

November 2025 in “Discover Pharmaceutical Sciences”

In this study, a nanoemulsion containing lavender, peppermint, and rosemary essential oils was developed and shown to promote hair growth in mice at a rate comparable to 2% topical minoxidil, suggesting a promising natural alternative due to its antioxidant and anti-inflammatory effects.

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Community Join

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community Why I Take 5mg Minoxidil at Night Instead of Splitting 2.5mg

9 upvotes 4 months ago

Taking 5mg oral minoxidil at night instead of splitting 2.5mg doses, with the rationale that a single larger dose may provide a stronger activation for hair follicles and reduce peak-related side effects. Some users report sleep issues with nighttime dosing, while others find it beneficial; opinions on effectiveness and side effects vary.

community What is the ultimate hair regrowth protocol

29 upvotes 1 year ago

The conversation covers aggressive hair regrowth treatments like Dutasteride, Minoxidil (oral and topical), RU58841, microneedling, and ketoconazole shampoo. It also mentions PRP, laser therapy, GHK-Cu injections, and hormone therapy for maximum regrowth.

community Finally, some real breakthroughs. A comparison of the two leading baldness treatments: PP405 versus ABS-201

106 upvotes 10 months ago

PP405 and ABS-201 are promising treatments for male pattern baldness. PP405 shows rapid hair growth in human trials, while ABS-201 shows significant regrowth in animal studies but is still in early human trials.

community Hair loss over a year following depression and taking antidepressants

in Side effects? 200 upvotes 8 months ago

A 33-year-old experienced significant hair loss after a depressive episode and taking paroxetine, possibly due to telogen effluvium or androgenic alopecia. Suggestions included reducing alcohol, considering finasteride and minoxidil, and consulting a doctor about antidepressant side effects.

community I asked Gemini 2.5 Pro to roast r/tressless

in Satire 35 upvotes 1 year ago

Hair loss concerns and treatments like Minoxidil and Finasteride are humorously discussed. The community's quirks and dedication to battling hair loss are highlighted.

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