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research 671 Impaired follicular Nrf2 signaling: Potential early therapeutic target in hidradenitis suppurativa

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that impaired Nrf2 signaling and its relationship with keratin 16 may contribute to follicular hyperkeratinization and occlusion in hidradenitis suppurativa, opening new therapeutic avenues.

research LB965 Follicular trochanters: A potential mechanism for stem cell depletion in scarring alopecia

June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that fibrosis-associated trochanters in central centrifugal cicatricial alopecia are enriched with hair follicle stem cells and may indicate a disrupted stem cell niche contributing to scarring.

research The upper dermal sheath has a potential to regenerate the hair in the rat follicular epidermis

31 citations , September 1996 in “Differentiation”

This study claims that the upper dermal sheath of rat vibrissa follicles can induce hair growth under specific conditions, challenging prior beliefs about its lack of inductive capacity.

research The most efficient follicular regenerating unit and the smallest follicular regenerating unit: Potential treatments for hair loss

2 citations , July 2009 in “Medical hypotheses”

This article discusses hair transplant techniques and hypothesizes that smaller regenerating units within hair follicles may allow for one-to-many transplantation, potentially increasing hair numbers for those with hair loss, but reports no new experimental results.

Histological Assessment of Follicular Delivery of Flutamide by Solid Lipid Nanoparticles: Potential Tool for the Treatment of Androgenic Alopecia

research Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: potential tool for the treatment of androgenic alopecia

42 citations , July 2015 in “Drug Development and Industrial Pharmacy”

This study concluded that Flutamide-loaded solid lipid nanoparticles may enhance hair follicle drug delivery and promote hair growth in androgenic alopecia compared to a Flutamide hydroalcoholic solution.

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community Information regarding Follicusan DP?

3 upvotes 2 years ago

Follicusan DP is discussed as a potential alternative to Minoxidil without side effects, but information is scarce. It is noted to be of German origin and details on its mechanism are limited.

community What is the deal with "longitudinal partial follicular unit transplantation"

3 upvotes 6 years ago

Longitudinal partial follicular unit transplantation involves extracting part of the donor follicular unit, allowing the donor area to maintain hair production and potentially increasing transplant yield. The conversation questions if this method is practiced in clinics or remains theoretical, and whether it relates to hair cloning or multiplication.

community Pelage PP405: New Hair Growth from Inactive Follicular Units - Phase 2a results at AAD 2026

1080 upvotes 5 months ago

PP405, a topical treatment, shows promise for hair growth by activating inactive follicles, with 66% of participants experiencing positive results. The treatment is well-tolerated and may proceed directly to Phase 3 trials, offering a potential alternative to minoxidil and finasteride.

community Targeted Follicular Finasteride Delivery: A Low-Systemic Strategy

15 upvotes 5 months ago

A peptide-based delivery system for finasteride shows promise in reducing systemic side effects while maintaining hair growth effectiveness. Combining this with other treatments like minoxidil and RU58841 could enhance results with lower systemic absorption.

community Dutasteride: More Than a DHT Reducer – A Potential Androgen Receptor Inhibitor?

in Finasteride/Dutasteride 31 upvotes 1 year ago

Dutasteride may inhibit androgen receptors in addition to reducing DHT, potentially explaining its effectiveness over finasteride for hair loss. Concerns about its impact on muscle growth are debated, with some suggesting no significant effects.

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