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Research

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Hair Diameter Diversity: A Clinical Sign Reflecting Follicle Miniaturization

research Hair diameter diversity: a clinical sign reflecting the follicle miniaturization.

41 citations , May 2001 in “PubMed”

This study proposes a new clinical scoring method for hair density based on hair diameter diversity, which correlates with existing measures and reflects follicle miniaturization in androgenetic alopecia.

research Foxc1 reinforces quiescence in self-renewing hair follicle stem cells

142 citations , February 2016 in “Science”

This review discusses the role of Foxc1 and type XVII collagen in hair follicle stem cell quiescence and aging, identifying mechanisms that relate to hair thinning and hair loss, and reports no new results.

research Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling

65 citations , September 2004 in “The American journal of pathology”

This study found that overexpressing the BMP inhibitor Noggin in transgenic mice led to a significant loss of nontylotrich hair follicles, suggesting a critical role for BMP signaling in hair follicle morphogenesis and cycling.

research Quiescent and aging hair follicle stem cells

February 2016 in “Science”

This research found that Foxc1 promotes quiescence in hair follicle stem cells and identified COL17A1 depletion, due to DNA damage, as a cause of hair thinning and loss during aging.

research Wound-initiated hair regeneration by adhesive and shrinkable materials

August 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that in mice, including middle-aged and aged specimens, creating a wound without dermal defects and using adhesive materials to separate the epidermis from the dermis induced new hair follicle formation, suggesting potential applications for treating hair loss.

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Community Join

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community Anyone that has been using peptides and seen hair results?

9 upvotes 7 months ago

Peptides, specifically GHK-Cu, are being considered for hair growth benefits, such as increasing blood flow to the scalp and preventing hair follicle shrinkage. A user reported starting GHK-Cu after hearing it made a friend's hair thicker.

community Demystifying PP405. It is not a mystery cure with constructive criticism as a proof! It is....!!!!

1 upvotes 1 year ago

PP405 is a growth stimulant drug that activates hair follicle stem cells but does not reverse miniaturization like finasteride. It is not a cure for hair loss and is not an alternative to minoxidil, but it may help grow hair if successful.

community Confused why people are calling PP405 a cure...it never claimed to be able to undo miniaturization or revert vellus back to terminal hairs. It seems to be more of a growth stimulant like minoxidil.

in Research/Science 55 upvotes 1 year ago

PP405 is not a cure for hair loss but may reactivate dormant hair follicles, similar to minoxidil. It is unlikely to help with miniaturized or vellus hairs and is still in trial phases, with availability expected around 2030.

community FtM: "Aggressive Regemin - Recovery From Norwood-6.5" Minoxodil/Estradiol valerate/Spironolactone. (What will happen in the worst case if CIS male go this way for a year?)

53 upvotes 5 years ago

User "Ant1pal" shares progress pictures of hair regrowth using Minoxidil, Estradiol valerate, and Spironolactone. Users discuss potential side effects and the possibility of localizing estrogen to hair follicles for better treatment.

community 8 months on 5mg fin daily, 5% min twice daily, and hrt(mtf). Thought my hair was unrecoverable before but now I’m so happy.

1902 upvotes 3 years ago

A user named "LordGeek101" shared their positive experience with hair regrowth after using 5mg of finasteride daily, 5% minoxidil twice daily, and hormone replacement therapy (HRT) for 8 months. The user is transgender (MTF) and mentioned that the larger dose of finasteride was recommended by their doctor for better chances of hair revival.

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Learn

6 / 801 results

learn Caffeine

the stimulant you know and love can be used topically to stimulate hair

learn Niacinamide

How does Niacinamide support the hair follicle’s nutrition? Niacinamide nourishes hair follicles by boosting energy production and supporting antioxidant defenses.

learn oleic acid

How does Oleic Acid support hair follicle strength and growth? Oleic acid strengthens hair follicles by enhancing hydration and reducing inflammation.

learn Scalp Micropigmentation

Will scalp micropigmentation damage my existing hair or follicles? Scalp micropigmentation does not damage existing hair or follicles.

learn Redensyl

Does Redensyl regenerate follicles or only strengthen existing hair? Redensyl primarily strengthens existing hair rather than regenerating new follicles.

learn KY19382

How does KY19382 actually stimulate dormant hair follicles to grow again? KY19382 stimulates dormant hair follicles by reactivating the Wnt/β-catenin signaling pathway.

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Clinics

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