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GlossaryFilaggrin

protein crucial for skin barrier function and hydration

Filaggrin is a protein found in the outermost layers of the skin that plays a crucial role in maintaining the skin's barrier function and hydration. It helps to aggregate keratin fibers, which strengthens the skin and protects against environmental damage. Deficiencies or mutations in the filaggrin gene are linked to skin conditions like eczema and ichthyosis vulgaris.

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research Filaggrin Mutations as an Archetype for Understanding the Pathophysiology of Atopic Dermatitis

3 citations , August 2014 in “Journal of The American Academy of Dermatology”

Filaggrin mutations are linked to atopic dermatitis and help explain how genetics and environment affect the disease.

research Frontal Fibrosing Alopecia: A Review of 355 Cases in a Spanish Population

9 citations , August 2014 in “Journal of The American Academy of Dermatology”

Hormonal imbalances may play a role in frontal fibrosing alopecia, and antiandrogenic drugs combined with steroids are currently the most effective treatment.

research Trichohyalin-Like Proteins Have Evolutionarily Conserved Roles in the Morphogenesis of Skin Appendages

68 citations , April 2014 in “Journal of Investigative Dermatology”

Trichohyalin-like proteins are essential for the development of skin structures like hair, nails, and feathers.

research Impaired Hair Follicle Morphogenesis and Cycling with Abnormal Epidermal Differentiation in Nackt Mice, a Cathepsin L-Deficient Mutation

57 citations , August 2002 in “American Journal Of Pathology”

Cathepsin L deficiency causes hair and skin issues in mice.

research Effects of Non-Ablative Fractional Erbium Glass Laser Treatment on Gene Regulation in Human Three-Dimensional Skin Models

24 citations , January 2016 in “Lasers in Medical Science”

Erbium glass laser treatment may help with skin remodeling, reduce inflammation, and improve skin cell maturation.

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