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Glossary Filaggrin

protein crucial for skin barrier function and hydration

Filaggrin is a protein found in the outermost layers of the skin that plays a crucial role in maintaining the skin's barrier function and hydration. It helps to aggregate keratin fibers, which strengthens the skin and protects against environmental damage. Deficiencies or mutations in the filaggrin gene are linked to skin conditions like eczema and ichthyosis vulgaris.

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research Filaggrin mutations as an archetype for understanding the pathophysiology of atopic dermatitis

3 citations , August 2014 in “Journal of The American Academy of Dermatology”

This article discusses the role of filaggrin gene mutations in understanding atopic dermatitis and their link to allergic sensitization but does not report new clinical results.

research Recombinant Filaggrin-2 microneedles reverse androgenetic alopecia by rescuing mitochondrial dysfunction in dermal papilla cells

March 2026 in “International Journal of Biological Macromolecules”

Recombinant Filaggrin-2 microneedles effectively promote hair growth and repair in hair loss.

Histologic Morphology and Involucrin, Filaggrin, and Keratin Expression in Normal Canine Skin from Dogs of Different Breeds and Coat Types

research Histologic morphology and involucrin, filaggrin, and keratin expression in normal canine skin from dogs of different breeds and coat types

15 citations , January 2012 in “Journal of Veterinary Science”

This study examined variations in epidermal thickness and protein expression across different dog breeds, finding significant differences by anatomical site and breed, with associated mRNA and protein expression changes observed.

Involucrin, But Not Filaggrin and Kdap mRNA, Expression Is Downregulated in 3-D Cultures of Intact Rat Hair Bulbs After Calcium Stimulation

research Involucrin, but not filaggrin and Kdap mRNA, expression is downregulated in 3-D cultures of intact rat hair bulbs after calcium stimulation

3 citations , July 2011 in “Folia Histochemica et Cytobiologica”

This study concluded that the inner root sheath inhibits the expression of certain differentiation markers in hair bulbs, with calcium-induced changes paralleling those seen in hair follicle mid-segments.

research Expression of epidermal keratins and filaggrin during human fetal skin development.

292 citations , October 1985 in “The Journal of Cell Biology”

This study observed that the expression of certain keratins during human epidermal development marks the tissue's commitment to stratification and keratinization processes.

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