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GlossaryFilaggrin

protein crucial for skin barrier function and hydration

Filaggrin is a protein found in the outermost layers of the skin that plays a crucial role in maintaining the skin's barrier function and hydration. It helps to aggregate keratin fibers, which strengthens the skin and protects against environmental damage. Deficiencies or mutations in the filaggrin gene are linked to skin conditions like eczema and ichthyosis vulgaris.

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research Filaggrin Mutations as an Archetype for Understanding the Pathophysiology of Atopic Dermatitis

3 citations, August 2014 in “Journal of The American Academy of Dermatology”

Filaggrin mutations are linked to atopic dermatitis and help explain how genetics and environment affect the disease.

research Effects of Non-Ablative Fractional Erbium Glass Laser Treatment on Gene Regulation in Human Three-Dimensional Skin Models

24 citations, January 2016 in “Lasers in Medical Science”

Erbium glass laser treatment may help with skin remodeling, reduce inflammation, and improve skin cell maturation.

Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts

research Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts

20 citations, January 2019 in “Journal of dermatological science”

Male hormones indirectly affect skin cell development by increasing growth factor levels from skin fibroblasts.

research Non-Invasive Human Skin Transcriptome Analysis Using mRNA in Skin Surface Lipids

10 citations, March 2022 in “Communications biology”

A new non-invasive method can analyze skin mRNA to understand skin diseases better.

research Non-Invasive Human Skin Transcriptome Analysis Using mRNA in Skin Surface Lipids

2 citations, April 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

The conclusion is that analyzing RNA from skin oils is a promising way to understand skin diseases.

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