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research Identification of immune microenvironment changes, immune-related pathways and genes in male androgenetic alopecia

September 2023 in “Medicine”

This study found increased infiltration of specific immune cells, such as γδ T cells and CD8+ T cells, in the bald scalp of male androgenetic alopecia patients, and identified four key immune-related genes potentially involved in hair loss development through interferon-γ signaling pathways.

research Deep phenotyping of skin tissue remodeling in patients with systemic sclerosis treated with CD19-CAR T cells

1 citations , May 2026 in “Nature Communications”

This study demonstrated that CD19-CAR T cell therapy may promote structural regeneration in the skin of systemic sclerosis patients, as evidenced by histological improvements and fibroblast population changes, suggesting its potential for tissue remodeling in fibrotic diseases.

research Issue Information

July 2020 in “Experimental Dermatology”

This discussion of age-related changes in female scalp hair follicles reports no new results, highlighting the structural transformations that may contribute to thinning hair in women as they age.

research 863 Central centrifugal cicatricial alopecia gene expression analysis revealed cholesterol, fatty acid, and mast cell pathways

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, researchers found that CCCA in women of African descent is associated with molecular changes, including dysregulation of fatty acid metabolism and fibrosis pathways, suggesting potential targets for new treatments.

research A Candidate Syndromic Triad of Acne Keloidalis Nuchae, Dissecting Cellulitis, and Secondary Cutis Verticis Gyrata

August 2026 in “Clinical Cosmetic and Investigational Dermatology”

This case series suggests that a combination of acne keloidalis nuchae, dissecting cellulitis of the scalp, and extensive cutis verticis gyrata may form a syndromic triad with significant inflammatory and fibrotic scalp changes.

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Community Join

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community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

59 upvotes 6 months ago

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

community 2 years of 5% topical minoxidil + 1 year of 1mg finasteride.

in Progress Pictures 236 upvotes 5 months ago

The user shared progress pictures after using 5% topical minoxidil for two years and 1mg finasteride for one year, but many commenters believe the hair looks the same, attributing changes to different haircuts rather than actual regrowth. The user reported no side effects from finasteride, and opinions varied on whether any significant hairline improvement occurred.

community Any point in microneedling if I use oral minoxidil?

in Microneedling 8 upvotes 6 months ago

The conversation discusses the use of microneedling as a complementary treatment for hair loss alongside oral minoxidil and dutasteride. Opinions vary on its effectiveness, with some users supporting its benefits for hair growth and others questioning its efficacy without topical minoxidil.

community Oral minoxidil timeframe (any late responders)

in Minoxidil 34 upvotes 9 months ago

Oral minoxidil, finasteride, and dutasteride are being used to treat hair loss, but results are limited, leading to consideration of a hair transplant. The user plans to continue medication for another year before deciding on further action.

community Is microneedling a risk if you want to have a hair transplant in the future?

in Transplants 13 upvotes 10 months ago

Microneedling may risk scarring, potentially complicating future hair transplants. Alternatives like tretinoin with minoxidil are suggested for better hair growth.

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