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Tumor Necrosis Factor Alpha, Interferon Gamma, and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin

research Tumor Necrosis Factor Alpha, Interferon Gamma, and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin

24 citations , April 2013 in “PLOS ONE”

TNFα, IFNγ, and Substance P significantly affect prolactin levels in human skin, suggesting new treatments for skin and hair conditions.

research Prolactin: An Emerging Force Along the Cutaneous–Endocrine Axis

51 citations , July 2010 in “Trends in Endocrinology and Metabolism”

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

research Prolactin and Hyperprolactinemia in Female Reproductive Endocrinology – An Update

February 2021 in “Facta Universitatis”

Too much prolactin can cause menstrual problems, infertility, and sexual issues in women.

research Serum Prolactin Levels in Adult Females with Telogen Effluvium: A Case Control Study

January 2021 in “Turkiye Klinikleri Journal of Dermatology”

Women with a certain type of hair loss had lower levels of a hormone called prolactin compared to healthy women.

research The Prolactin Receptor as a Therapeutic Target in Human Diseases: Exploring New Potential Indications

38 citations , June 2015 in “Expert Opinion on Therapeutic Targets”

Blocking the prolactin receptor might help treat various diseases, but more research is needed.

View more "extrapituitary prolactin" in research →

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community Why HMI115 should work if it doesn’t affect dht?

in Research/Science 16 upvotes 2 years ago

Hair growth can be induced without stopping DHT, as seen with Minoxidil. HMI115 may work by promoting follicle growth, not targeting the root cause of hair loss (DHT).

community A New Hair Loss Drug Could Cure Balding and Reverse Graying

in Research/Science 368 upvotes 4 months ago

ABS-201, a prolactin receptor blocker, shows promise in reversing hair loss and graying, with early success in macaques. Current treatments like finasteride, minoxidil, and RU58841 are still widely used, but new options like PP405 are eagerly anticipated.