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research Neuronal Model of Tactile Allodynia Produced by Spinal Strychnine: Effects of Excitatory Amino Acid Receptor Antagonists and a Mu-Opiate Receptor Agonist

80 citations , December 1996 in “Pain”

Disruption of glycinergic circuits increases pain sensitivity, suggesting new pain treatment options.

Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABA A Miniature IPSCs in Lamina II of the Spinal Cord

research Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABA A Miniature IPSCs in Lamina II of the Spinal Cord

88 citations , January 2004 in “Journal of Neuroscience”

Neurosteroids regulate synaptic inhibition in the spinal cord and may help manage spinal pain.

research Spinal Bicuculline Produces Hypersensitivity of Dorsal Horn Neurons: Effects of Excitatory Amino Acid Antagonists

99 citations , August 1998 in “Pain”

Blocking GABA(A) receptors increases neuron sensitivity, showing GABA and glycine have different roles in pain.

research Sigma-1 Receptor-Related Neuroactive Steroids Modulate Cocaine-Induced Reward

100 citations , May 2003 in “Journal of Neuroscience”

Neuroactive steroids affect cocaine's rewarding effects through the ς₁ receptor.

research Prolactin and the Skin: A Dermatological Perspective on an Ancient Pleiotropic Peptide Hormone

98 citations , December 2008 in “Journal of Investigative Dermatology”

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

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community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 1 year ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community Finasteride does deplete important nuero-active steroids

in Research/Science 9 upvotes 2 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.