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Key Targets of Hormonal Treatment of Prostate Cancer: The Androgen Receptor and 5α-Reductase

research Key targets of hormonal treatment of prostate cancer. Part 2: the androgen receptor and 5α-reductase

29 citations , July 2009 in “BJU international”

This review examines the pharmacological properties and potential clinical benefits of 5α‐reductase inhibition in prostate cancer but reports no new research findings.

research 5α- Reductase Inhibitors in Prostate Cancer: An Overview

April 2017 in “Austin Journal of Cancer and Clinical Research”

This article reviews the role and controversies of 5α-reductase inhibitors like finasteride and dutasteride in managing prostate cancer, without presenting new research results.

research Androgenetic alopecia: a review

153 citations , March 2017 in “Endocrine”

This review examines recent advances in understanding the pathophysiology and molecular mechanisms of androgenetic alopecia, highlighting two major genetic risk loci, but does not report new clinical findings.

research Immunohistochemical localization of types 1 and 2 5α-reductase in human scalp

100 citations , September 1999 in “British Journal of Dermatology”

This study suggests that finasteride's effect on promoting hair growth in men with androgenetic alopecia may be due to its inhibition of 5aR2 localized in hair follicles.

research Preventive and Therapeutic Efficacy of Finasteride and Dutasteride in TRAMP Mice

9 citations , October 2013 in “PLOS ONE”

This study suggests that dutasteride may be more beneficial than finasteride for therapeutic or preventive use.

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community Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling

23 upvotes 10 months ago

Fatty acid metabolic signaling can activate epithelial stem cells for hair regeneration. Oleic and palmitoleic acids showed the best results, but practical application on humans remains uncertain.

community 5ar Type I in the frontal hair follicles - Dutasteride

in Finasteride/Dutasteride 21 upvotes 2 years ago

The conversation discusses that dutasteride may be more effective than finasteride for frontal hair loss due to higher 5ar Type 1 enzyme activity in that area. Some users question the validity of this information, while others confirm it with additional sources.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

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