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Expression of Type 1 5α-Reductase and Metabolism of Testosterone in Reconstructed Human Epidermis: A New Model for Screening Skin-Targeted Androgen Modulators

research Expression of Type 1 5α-Reductase and Metabolism of Testosterone in Reconstructed Human Epidermis: A New Model for Screening Skin-Targeted Androgen Modulators

3 citations, December 2000 in “International Journal of Cosmetic Science”

The study created a new method to test drugs that affect hormone processing in skin.

research Acne Protection: Measures and Miseries

January 2019 in “ARC journal of pharmaceutical sciences”

Acne can be managed with various treatments and requires psychological support due to its emotional impact.

Neonatal Inhibition of Androgen Activity Alters the Programming of Body Weight and Orexinergic Peptides Differentially in Male and Female Rats

research Neonatal Inhibition of Androgen Activity Alters the Programming of Body Weight and Orexinergic Peptides Differentially in Male and Female Rats

February 2024 in “Brain research bulletin”

Blocking androgen activity in newborn rats affects body weight and appetite-related hormones differently in males and females.

research Female Pattern Hair Loss: Therapeutic Update

March 2023 in “Anais Brasileiros De Dermatologia”

Topical minoxidil is the best-supported treatment for female hair loss, but personalized plans are needed.

Polymeric Micelle Mediated Follicular Delivery of Spironolactone: Targeting the Mineralocorticoid Receptor to Prevent Glucocorticoid-Induced Activation and Delayed Cutaneous Wound Healing

research Polymeric Micelle Mediated Follicular Delivery of Spironolactone: Targeting the Mineralocorticoid Receptor to Prevent Glucocorticoid-Induced Activation and Delayed Cutaneous Wound Healing

9 citations, June 2021 in “International Journal of Pharmaceutics”

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.

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community Sharing my (relatively short) Success Story

paulsac11 in Progress Pictures 77 upvotes 1 year ago

A user named "paulsac11" shares their success story of treating hair loss. They started with topical minoxidil, then switched to oral minoxidil and dutasteride. They also used a shampoo and conditioner from Keeps. After eight months of treatment, they have seen significant improvement in their hairline.

community UPDATE: The theory that explains everything. Please help me make this big!

joaopassos4444 in Research/Science 448 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community The theory that explains everything - First Evidence of Hair regrow attributed to upregulating 3aHSD

joaopassos4444 in Treatment 175 upvotes 3 years ago

Hair regrowth treatment involving 3aHSD enzyme shows 6% improvement in 18 weeks. Sulforaphane, L-Menthol, and Dexpanthenol are potential ingredients for new hair loss solution.

community Is it a normal shed or is it fin not working (or making things worse)

nima_gj in Finasteride/Dutasteride 7 upvotes 2 years ago

The user experienced hair shedding after switching from minoxidil to finasteride and is considering switching to dutasteride or stopping pills altogether. They also stopped using a specific shampoo with probiotics, enzymatic exfoliator, zinc, and panthenol.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

noeyys in Research/Science 62 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

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