learn Osteopontin signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
research Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the Niche January 2006 in “Yearbook of Dermatology and Dermatologic Surgery” Hair graying is caused by the loss of pigment cells due to poor maintenance of stem cells in the hair follicle.
research Aging of the Hair Follicle Pigmentation System 75 citations, January 2009 in “International journal of trichology” Hair grays due to oxidative stress and fewer functioning melanocytes.
research EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling 59 citations, April 2016 in “Cell Reports” EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.
research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration 260 citations, June 2011 in “Cell” Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
research From Neural Crest Cells to Melanocytes: Cellular Plasticity During Development and Beyond 66 citations, March 2019 in “Cellular and Molecular Life Sciences” Melanocyte development from neural crest cells is complex and influenced by many factors, and better understanding could help treat skin disorders.