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      research When Rare Meets Risky: Clouston Syndrome with Cutaneous Squamous Cell Carcinoma

      November 2025 in “Indian Dermatology Online Journal”
      A 20-year-old male with Clouston syndrome, characterized by alopecia, nail dystrophy, and palmoplantar keratoderma, developed cutaneous squamous cell carcinoma (SCC) on his right great toe. Despite treatment for chronic paronychia, the condition persisted, leading to the discovery of SCC, which was surgically treated with toe amputation. This case is notable as the first reported instance of Clouston syndrome presenting with cutaneous SCC, emphasizing the importance of monitoring for SCC in patients with chronic paronychia and Clouston syndrome. The patient's family history revealed similar symptoms in multiple relatives, indicating a hereditary pattern.
      Clouston’s Syndrome: A Rare Case Report

      research Clouston’s Syndrome: A Rare Case Report

      August 2020 in “International Journal of Research in Dermatology”
      Clouston's syndrome is a rare disorder affecting nails, hair, teeth, and skin, caused by a gene mutation, and currently has no treatment, only supportive care.

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