When Rare Meets Risky: Clouston Syndrome with Cutaneous Squamous Cell Carcinoma
November 2025
in “
Indian Dermatology Online Journal
”
Studysummary This case report describes a patient with Clouston syndrome who developed squamous cell carcinoma, highlighting the need for regular follow-up in patients with chronic paronychia that do not respond to conventional treatments.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
A 20-year-old male with Clouston syndrome, characterized by alopecia, nail dystrophy, and palmoplantar keratoderma, developed cutaneous squamous cell carcinoma (SCC) on his right great toe. Despite treatment for chronic paronychia, the condition persisted, leading to the discovery of SCC, which was surgically treated with toe amputation. This case is notable as the first reported instance of Clouston syndrome presenting with cutaneous SCC, emphasizing the importance of monitoring for SCC in patients with chronic paronychia and Clouston syndrome. The patient's family history revealed similar symptoms in multiple relatives, indicating a hereditary pattern.
