Clouston Syndrome Associated With Eccrine Syringofibroadenoma

Eccrine syringofibroadenoma is a rare benign tumor originating from eccrine sweat gland cells, typically affecting the extremities of elderly individuals. It can appear as solitary or multiple lesions, with its pathogenesis and differentiation remaining controversial. This condition has been linked to underlying disorders like hypohidrotic ectodermic dysplasias. The document detailed a case report of a patient with Clouston Syndrome who exhibited papules and nodules on the extremities, which were clinically and histologically consistent with eccrine syringofibroadenoma. This case was notable as it was only the fourth instance reported in the literature of such an association with Clouston Syndrome.