When Rare Meets Risky: Clouston Syndrome with Cutaneous Squamous Cell Carcinoma

A 20-year-old male with Clouston syndrome, characterized by alopecia, nail dystrophy, and palmoplantar keratoderma, developed cutaneous squamous cell carcinoma (SCC) on his right great toe. Despite treatment for chronic paronychia, the condition persisted, leading to the discovery of SCC, which was surgically treated with toe amputation. This case is notable as the first reported instance of Clouston syndrome presenting with cutaneous SCC, emphasizing the importance of monitoring for SCC in patients with chronic paronychia and Clouston syndrome. The patient's family history revealed similar symptoms in multiple relatives, indicating a hereditary pattern.