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November 2023 in “Journal of Microbiology and Biotechnology” The study successfully established immortalized human dermal papilla cells (HDPCs) by transfecting them with human papillomavirus 16 (HPV16) E6/E7 oncogenes, overcoming the limitations of primary HDPCs such as reduced proliferative capacity and hair induction potential. These immortalized cells demonstrated higher proliferative activity, with downregulated p53 and pRb proteins and decreased expression of the CDK inhibitor p21. Additionally, cell cycle-related genes and proteins, including CDK2, cyclin E, and E2F family genes, were upregulated. Importantly, the immortalized HDPCs retained their ability to respond to the Wnt/β-catenin pathway and form hair follicles, making them valuable for in vitro hair growth and regeneration studies.
27 citations
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January 2012 in “Current Topics in Microbiology and Immunology” Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.
178 citations
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May 2006 in “Developmental Dynamics” Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.
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April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Goat skin changes with the seasons due to genes affected by daylight and hormones.
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May 2017 in “InTech eBooks” Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.